We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 3

1.
Figure 2

Figure 2. From: CoA Adducts of 4-Oxo-4-phenylbut-2-enoates: Inhibitors of MenB from the M. tuberculosis Menaquinone Biosynthesis Pathway.

HTS hits containing the OSB core. These compounds were identified in the initial HTS screen conducted using the MenE/MenB coupled assay.

Xiaokai Li, et al. ACS Med Chem Lett. 2011 November 10;2(11):818-823.
2.
Figure 1

Figure 1. From: CoA Adducts of 4-Oxo-4-phenylbut-2-enoates: Inhibitors of MenB from the M. tuberculosis Menaquinone Biosynthesis Pathway.

Menaquinone biosynthesis pathway. This pathway converts chorismate to menaquinone in prokaryotes such as E. coli, S. aureus, B. subtilis, and M. tuberculosis. Shown in detail are the reactions catalyzed by the OSB-CoA synthase MenE and the 1,4,-dihydroxy-2-naphthoyl-CoA synthase MenB.

Xiaokai Li, et al. ACS Med Chem Lett. 2011 November 10;2(11):818-823.
3.
Figure 3

Figure 3. From: CoA Adducts of 4-Oxo-4-phenylbut-2-enoates: Inhibitors of MenB from the M. tuberculosis Menaquinone Biosynthesis Pathway.

Proposed structure of a CoA adduct bound to MenB. (a) Proposed structure of the CoA adduct bound to MenB. The CoA adduct adopts a structure that mimics the resonance-stabilized carbanion formed during the MenB-catalyzed reaction. (b) The 2,4-dichloro CoA adduct (16) modeled into the active site of MenB. This model was built using the structure of acetoacetyl-CoA bound to MenB (1Q51.pdb)8 and shows the proposed interaction between the adduct carboxylate and the MenB oxyanion hole (G105 and G161). Also shown are three conserved MenB residues (S190, D192, and Y′287). The figure was made using pymol.23

Xiaokai Li, et al. ACS Med Chem Lett. 2011 November 10;2(11):818-823.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk