Results: 2

1.
Figure 2

Figure 2. From: Proteomic Changes in Cerebrospinal Fluid of Presymptomatic and Affected Persons Carrying Familial Alzheimer Disease Mutations.

Network 2 (metabolic disease, renal and urologic disease, and molecular transport) generated by pathway analysis of the hot list. This network is also displayed as nodes (genes or gene products) and edges. Fx indicates function. *Indicates that components mapped to multiple protein database entries of a single gene. For further explanation of the lines and symbols used, see Figure 1 and its legend.

John M. Ringman, et al. Arch Neurol. 2012 January;69(1):96-104.
2.
Figure 1

Figure 1. From: Proteomic Changes in Cerebrospinal Fluid of Presymptomatic and Affected Persons Carrying Familial Alzheimer Disease Mutations.

Network 1 (antigen presentation, cell-mediated immune response, and humoral immune response) generated by pathway analysis of the hot list. This network is displayed as nodes (genes or gene products) and edges. “Acts on” and “inhibits” edges may also include a binding event. Lines indicate biological relationships between nodes. Blue proteins are downregulated in individuals who are mutation carriers, and red proteins are upregulated. Uncolored proteins were not found to be different in our study but are linked by pathway analyses. Fx indicates function.

John M. Ringman, et al. Arch Neurol. 2012 January;69(1):96-104.

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