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Figure 1

Figure 1. From: Enrichment of Cis-Regulatory Gene Expression SNPs and Methylation Quantitative Trait Loci Among Bipolar Disorder Susceptibility Variants.

Top susceptibility loci from the Wellcome Trust genome-wide association study of Bipolar Disorder are significantly enriched for cis mQTLs. The distribution of the number of cis mQTLs in 1,000 draws (each of same count as the number of susceptibility loci tested) of frequency-matched variants is shown in the bar graphs, with the actual number of cis mQTLs observed in Wellcome Trust study shown as a solid circle. The expected value for the cis mQTL count was 108.9 (with standard deviation of 9.7) while the observed count was 132, which yields an enrichment p value of 0.01.

ER Gamazon, et al. Mol Psychiatry. 2013 March;18(3):340-346.

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