We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 5

2.
Figure 3

Figure 3. From: The Chemistry of Peptidyltransferase Center-Targeted Antibiotics: Enzymatic Resistance and Approaches to Countering Resistance.

Deuterium labeling patterns observed in RlmN and the proposed RlmN mechanism. a) The observed incorporation and retention of deuterium from various labeling experiments carried out with RlmN. b) The mechanism of catalysis by RlmN proposed by Grove et al (modified from reference 34).

Kevin P. McCusker, et al. ACS Chem Biol. 2012 January 20;7(1):64-72.
3.
Figure 4

Figure 4. From: The Chemistry of Peptidyltransferase Center-Targeted Antibiotics: Enzymatic Resistance and Approaches to Countering Resistance.

Erythromycin and telithromycin bound to E. coli ribosomes. Critical residues are indicated. The RNA backbone is shown as an orange ribbon; the protein chain is shown as a gray ribbon. Erythromycin is colored fuschia and telithromycin is colored light blue. The figure was generated using Pymol from PDB files 3OAT and 3OFR.

Kevin P. McCusker, et al. ACS Chem Biol. 2012 January 20;7(1):64-72.
4.
Figure 5

Figure 5. From: The Chemistry of Peptidyltransferase Center-Targeted Antibiotics: Enzymatic Resistance and Approaches to Countering Resistance.

Linezolid and torezolid in Deinococcus radiodurans ribosomes. The 8-methyl group on A2503 was modeled using Pymol. a) Linezolid is shown in fuschia (from PDB file 3DLL). b) Torezolid is shown in light blue; the acetamidomethyl pendant group of linezolid was replaced by the hydroxymethyl of torezolid in Pymol. The distance—in angstroms, demarcated by a dashed blue line—between the C-8 methyl on A2503 and the nearest heavy atom of the antibiotic is indicated in both a and b.

Kevin P. McCusker, et al. ACS Chem Biol. 2012 January 20;7(1):64-72.
5.
Figure 2

Figure 2. From: The Chemistry of Peptidyltransferase Center-Targeted Antibiotics: Enzymatic Resistance and Approaches to Countering Resistance.

RNA modifications and polar methylation mechanisms. a) Methylated bases, labeled with the modification and representative enzymes responsible for the transformation. Superscripts denote the position of modification on an RNA base; subscripts indicate the stoichiometry of methylation; 2′-O methylation is indicated by an m following the base that is ribose methylated. b) Mechanism of N-methylation by a SAM-dependent methyltransferase, e.g. Erm. c) Mechanism of C5 methylation by a SAM-dependent methyltransferase, e.g. RsmB. In both b and c, pt is used to indicate a proton transfer has taken place but is not shown explicitly.

Kevin P. McCusker, et al. ACS Chem Biol. 2012 January 20;7(1):64-72.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk