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Results: 12

1.
Figure 1

Figure 1. From: Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice.

Representative confocal image of the BNST delineating subregions in which IR was quantified.

Kristen E. Pleil, et al. Neuropharmacology. ;62(4):1777-1786.
2.
Figure 8

Figure 8. From: Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice.

Pooled data showing that bath application of BIIE 0246 did not alter the percent baseline of eIPSC peak amplitude in the dlBNST of naïve and chronically stressed C57B1/6J (A) and DBA/2J mice (B).

Kristen E. Pleil, et al. Neuropharmacology. ;62(4):1777-1786.
3.
Figure 9

Figure 9. From: Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice.

Representative confocal images of NPY-IR in the BNST of naïve C57BL/6J (A) and DBA/2J mice (B), and stressed C57BL/6J (C) and DBA/2J mice (D) 24 hrs after 10 consecutive days of restraint stress, taken with 10X objective.

Kristen E. Pleil, et al. Neuropharmacology. ;62(4):1777-1786.
4.
Figure 4

Figure 4. From: Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice.

Quantification of intensity values for NPY-IR (left column) and Y2R-IR (right column) in subregions of the BNST of C57BL/6J and DBA/2J mice, showing no differences between strains in protein expression, except a trend for greater NPY-IR in DBA/2J mice in the oval nucleus (p = 0.052).

Kristen E. Pleil, et al. Neuropharmacology. ;62(4):1777-1786.
5.
Figure 11

Figure 11. From: Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice.

Representative confocal images of Y2R-IR in the BNST of naïve C57BL/6J (A) and DBA/2J mice (B), and stressed C57BL/6J (C) and DBA/2J mice (D) 24 hrs after 10 consecutive days of restraint stress, taken with 10X objective.

Kristen E. Pleil, et al. Neuropharmacology. ;62(4):1777-1786.
6.
Figure 3

Figure 3. From: Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice.

A–D) Representative confocal images of NPY-IR (left column) and Y2R-IR (right column) in the BNST of naïve C57BL/6J (A and B) and DBA/2J mice (C and D). E and F) Tissue processed for immunohistochemistry without primary antibody solution to serve as negative controls. All images were taken with 10X objective.

Kristen E. Pleil, et al. Neuropharmacology. ;62(4):1777-1786.
7.
Figure 12

Figure 12. From: Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice.

Quantification of Y2R-IR in subregions of the BNST of C57BL/6J (left column) and DBA/2J mice (right column), presented as a percent of the average naïve values. Chronic stress increased Y2R protein expression in DBA/2J mice in the oval (B; 32%, t(15) = 3.39, p = 0.004), dorsal non-oval (D; 21%, t(15) = 2.12, p = 0.051), and ventral (F; 28%, t(15) = 3.08, p = 0.008) subregions.

Kristen E. Pleil, et al. Neuropharmacology. ;62(4):1777-1786.
8.
Figure 7

Figure 7. From: Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice.

The CV of eIPSC peak amplitude was increased after NPY application compared to baseline values in naïve (t(9) = 2.90, p = 0.018) but not stressed C57B1/6J mice (A), and a similar pattern was observed in DBA/2J mice (B; naïve: t(5) = 2.54, p = 0.05). PPR of eIPSCs was increased in naïve (t(9) = 2.93, p = 0.017) but not stressed C57BL/6J mice (C), and no changes were observed in DBA/2J mice (D).

Kristen E. Pleil, et al. Neuropharmacology. ;62(4):1777-1786.
9.
Figure 10

Figure 10. From: Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice.

Quantification of NPY-IR in subregions of the BNST of C57BL/6J (left column) and DBA/2J mice (right column), presented as a percent of the average naïve values. Chronic stress increased NPY protein expression in DBA/2J mice in the oval (B; 20%, t(18) = 2.76, p = 0.013), dorsal non-oval (D; 15%, t(18) = 2.04, p = 0.057), and ventral (F; 22%, t(18) = 2.73, p = 0.014) subregions.

Kristen E. Pleil, et al. Neuropharmacology. ;62(4):1777-1786.
10.
Figure 5

Figure 5. From: Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice.

Basal inhibitory transmission in C57B1/6J (left column) and DBA/2J mice (right column) from whole-cell recordings in the dlBNST. While sIPSC frequency was not altered by chronic stress in C57BL/6J mice (A), it was increased three-fold in DBA/2J mice (Welch-corrected t(10) = 4.20, p = 0.002). Stress did not alter the basal sIPSC amplitude in C57BL/6J (C) or DBA/2J mice (D). Representative sIPSC traces are shown for C57BL/6J (E) and DBA/2J mice (F; scale bar dimensions are 500 ms and 20 pA, respectively).

Kristen E. Pleil, et al. Neuropharmacology. ;62(4):1777-1786.
11.
Figure 2

Figure 2. From: Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice.

A and B) Pooled data showing that pre-application of the Y2R antagonist BIIE 0246 (1μM), but not the Y1R antagonist BIBP 3226 (1μM), blocks the effect of bath application of NPY on the percent baseline eIPSC peak amplitude in the dlBNST of naïve C57B1/6J (A) and DBA/2J mice (B). C and D) Bar graphs illustrating that NPY-induced inhibition of GABAergic transmission is significantly blunted by BIIE 0246 in C57BL/6J (C; t(7) = 3.70, p = 0.008) and DBA/2J mice (D; t(7) = 5.64, p < 0.001).

Kristen E. Pleil, et al. Neuropharmacology. ;62(4):1777-1786.
12.
Figure 6

Figure 6. From: Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice.

A and B) Pooled data showing the effect of bath application of NPY on the percent baseline eIPSC peak amplitude in the dlBNST of naïve and chronically stressed C57B1/6J (A) and DBA/2J mice (B). C and D) Bar graphs illustrating that NPY-induced inhibition of GABAergic transmission is significantly blunted 24 hrs after chronic restraint stress in DBA/2J (D; t(11) = 2.55, p = 0.027), but not C57BL/6J (C), mice. E and F) Average representative eIPSC traces during 5 min baseline and washout periods illustrating the NPY-induced inhibition of eIPSC peak amplitude in naïve (E, left) and stressed (E, right) C57BL/6J mice and naïve (F, left) and stressed (F, right) DBA/2J mice (scale bar dimensions are 20 ms and 100 pA, respectively).

Kristen E. Pleil, et al. Neuropharmacology. ;62(4):1777-1786.

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