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Results: 5

1.
Figure 1

Figure 1. From: Aspirin induces apoptosis in vitro and inhibits tumor growth of human hepatocellular carcinoma cells in a nude mouse xenograft model.

Effect of aspirin on the viability of HepG2 cells. The cells were treated with different concentrations of aspirin for 24 h, and then percentage of cell survival was determined using the MTT assay. Results are expressed as percentage of the vehicle treated control ± SEM of three separate experiments. (**p<0.01 vs. untreated control cells).

MOHAMMAD AKBAR HOSSAIN, et al. Int J Oncol. 2012 April;40(4):1298-1304.
2.
Figure 2

Figure 2. From: Aspirin induces apoptosis in vitro and inhibits tumor growth of human hepatocellular carcinoma cells in a nude mouse xenograft model.

Induction of apoptosis in HepG2 cells by aspirin. Cells were incubated with different concentrations of aspirin for 24 h. (A) DNA fragmentation was detected by 1.5% agarose gel containing EtBr. (B) Bax and Bcl-2 protein expressions in HepG2 cells treated with aspirin were analyzed by western blot analysis using anti-Bax and anti-Bcl-2 antibodies and ECL detection. Actin was used as an internal control. A representative blot is shown from three independent experiments.

MOHAMMAD AKBAR HOSSAIN, et al. Int J Oncol. 2012 April;40(4):1298-1304.
3.
Figure 5

Figure 5. From: Aspirin induces apoptosis in vitro and inhibits tumor growth of human hepatocellular carcinoma cells in a nude mouse xenograft model.

Aspirin inhibits xenograft HepG2 tumor growth. (A) Tumor growth curve. The volume of each tumor was measured twice a week after 4 weeks. The average tumor volume in vehicle-treated control mice and treated with aspirin is plotted. (**p<0.01 vs. vehicle-treated control group). (B) Final tumor weight at 7 weeks. (*p<0.05 vs. vehicle-treated control group). (C) Body weight changes during the experiment. (D) Liver weight at 7 weeks.

MOHAMMAD AKBAR HOSSAIN, et al. Int J Oncol. 2012 April;40(4):1298-1304.
4.
Figure 3

Figure 3. From: Aspirin induces apoptosis in vitro and inhibits tumor growth of human hepatocellular carcinoma cells in a nude mouse xenograft model.

Aspirin induces the expression of (A) apoptotic related protein levels and (B) caspase cascade in HepG2 cells. After 24 h of incubation with aspirin, total cell lysates were prepared and immunoblotted. Western blots were detected with corresponding antibodies and ECL detection. Actin was used as an internal control. A representative blot is shown from three independent experiments. (C) Activation of caspase-3, -8, and -9 in HepG2 cells. Cells were treated with aspirin for 24 h at indicated concentration and then levels of caspase activity were measured. Data are expressed as mean ± SEM of three independent experiments.

MOHAMMAD AKBAR HOSSAIN, et al. Int J Oncol. 2012 April;40(4):1298-1304.
5.
Figure 4

Figure 4. From: Aspirin induces apoptosis in vitro and inhibits tumor growth of human hepatocellular carcinoma cells in a nude mouse xenograft model.

Aspirin inhibits growth of HepG2 cell xenograft in nude mice. (A) Experimental protocols in BALB/c nude mice. All mice were divided into two groups of 6 mice each, control and aspirin. Nude mice at 7 weeks of age were injected s.c. with 7.5×106 HepG2 cells. After 1 day, mice were treated with aspirin at 100 mg/kg/dose or with 0.5% CMC in water as a vehicle control orally for the entire 7-week experimental period. (B) The mice with xenograft HepG2 cells of both groups. (C) Tumor images of both control and aspirin group. (D) Histopathological sections of the xenograft tumor (arrows) and stomach in nude mice of control group (a and b) and aspirin group (c and d), respectively. Representative images are shown from in vivo experiments. Bar, 100 μm.

MOHAMMAD AKBAR HOSSAIN, et al. Int J Oncol. 2012 April;40(4):1298-1304.

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