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Figure 1

Figure 1. From: Cannabinoid Hyperemesis Syndrome.

Two well-characterized naturally occurring endocannabinoids are anandamide and 2-arachidonoylglycerol. Cannabinoids discovered in the cannabis plant with known effects on the regulation of emesis include tetrahydrocannabinol, cannabidiol, and cannabigerol.

Jonathan A. Galli, et al. Curr Drug Abuse Rev. ;4(4):241-249.
Figure 2

Figure 2. From: Cannabinoid Hyperemesis Syndrome.

The cannabinoids demonstrate opposing effects on the emesis response. A disruption in this balance causing the pro-emetic properties to overcome the anti-emetic effects may explain the paradox observed in cannabinoid hyperemesis syndrome. Abbreviations: CBD: cannabidiol, CBG: cannabigerol, THC: tetrahydrocannabinol.

Jonathan A. Galli, et al. Curr Drug Abuse Rev. ;4(4):241-249.

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