Results: 2

1.
Figure 1

Figure 1. From: Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas.

Fbxw7 mRNA levels in thymus. Fbxw7 expression levels are calculated relative to wild-type mice. Each genotype represents data taken from 3 animals.

Kuang-Yu Jen, et al. Blood. 2012 January 19;119(3):805-809.
2.
Figure 2

Figure 2. From: Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas.

Model of sequential genetic alterations in T-ALL. After ionizing radiation exposure, Tp53 levels increased as a result of DNA damage, which elicited an increase in Fbxw7 levels and a subsequent reduction in overall Notch1 activity. Genetic alterations opposing these changes arose sequentially in Notch1, Fbxw7, and Tp53 to yield T-ALL formation (A). In contrast, thymocytes with only 1 copy of Fbxw7 bypassed Notch1 mutations during malignant transformation (B). Paradoxically, thymocytes entirely lacking Tp53 underwent malignant transformation without Fbxw7 alteration but still displayed Notch1 mutations (C).

Kuang-Yu Jen, et al. Blood. 2012 January 19;119(3):805-809.

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