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Results: 3

1.
Figure 2

Figure 2. From: Genetic Variants in Interferon Regulatory Factor 2 (IRF2) are Associated with Atopic Dermatitis and Eczema Herpeticum.

Association of IRF2 SNP rs13139310 with IFNγ production. IFNγ production was determined by the log10-transformed mean SFC/106 cells and expressed as Spot Forming Units (SFU). IRF2 SNP rs13139310 was significantly associated with HSV-stimulated IFNγ levels (GG (n=44) vs GA+AA (n=12), P = 0.008).

Pei-Song Gao, et al. J Invest Dermatol. ;132(3):650-657.
2.
Figure 3

Figure 3. From: Genetic Variants in Interferon Regulatory Factor 2 (IRF2) are Associated with Atopic Dermatitis and Eczema Herpeticum.

IRF2 gene expression was decreased in VV-treated non-lesional skin biopsies from human subjects with ADEH compared with subjects with AD. a) IRF2 expression was detected by geneChip array in VV-treated non-lesional skin biopsies from ADEH patients (n = 5), AD patients (n=11), and non-atopic controls (NA, n=13). Y axis represents the fold changes for both AD and ADEH relative to NA. P value was determined by comparison made between mean fold changes for AD and ADEH. b) IRF2 expression was validated by qRT-PCR in VV-treated non-lesional skin biopsies from ADEH (n=8) and AD (n=10) patients. IRF2 expression was normalized to the corresponding GAPDH and expressed as IRF2 mRNA expression relative to GAPDH expression (2−ΔCt).

Pei-Song Gao, et al. J Invest Dermatol. ;132(3):650-657.
3.
Figure 1

Figure 1. From: Genetic Variants in Interferon Regulatory Factor 2 (IRF2) are Associated with Atopic Dermatitis and Eczema Herpeticum.

Haplotype results showing Omnibus P-values constructed across sliding windows of sizes 2–5 for 78 IRF2 SNPs and AD (a) and ADEH (b). Black vertical lines represent all individual SNP tests, and colored horizontal lines represent 2-, 3, 4, 5, haplotype tests. *See detailed data in Table 2. Lower plots illustrate patterns of LD (D’) in these samples: red squares for strong LD, blue squares for non-significant LD, and white squares for little or no LD; numerical values were generated using HAPLOVIEW software.

Pei-Song Gao, et al. J Invest Dermatol. ;132(3):650-657.

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