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1.
Figure 2

Figure 2. From: Identification of Six Loci Associated With Pelvic Organ Prolapse Using Genome-Wide Association Analysis.

Genome-wide Manhattan association results for pelvic organ prolapse. P-values are represented as −log (P-value). Results are taken from Efficient Mixed Model Association eXpedited software. The line represents the genome-wide significance threshold of 1×10−7. The green dots represent the six significant markers in the study.

Kristina Allen-Brady, et al. Obstet Gynecol. ;118(6):1345-1353.
2.
Figure 1

Figure 1. From: Identification of Six Loci Associated With Pelvic Organ Prolapse Using Genome-Wide Association Analysis.

The quantile–quantile plot for this analysis shows little evidence for inflation of the test statistic because of hidden population substructure, cryptic relatedness, or differential genotype calling between cases and controls. The genomic inflation factor (λGC) for this study was 1.05. The plot was made using association results from Efficient Mixed Model Association eXpedited software.

Kristina Allen-Brady, et al. Obstet Gynecol. ;118(6):1345-1353.
3.
Figure 3

Figure 3. From: Identification of Six Loci Associated With Pelvic Organ Prolapse Using Genome-Wide Association Analysis.

Plots of the six chromosomal regions found to be of interest. Gene plots are based on NCBI35/hg17. Estimated underlying recombination rates for a region are based on HapMap CEU individuals and are shown in blue. Markers in high linkage disequilibrium with one of the six single nucleotide polymorphisms (SNPs) of interest are determined using r-squared values obtained from HapMap CEU and are coded by the color of the diamond shape. White indicates no linkage disequilibrium (r2<0.2), yellow indicates weak linkage disequilibrium (r2 between 0.2 and 0.5), orange indicates moderate linkage disequilibrium (r2 between 0.5 and 0.8), and red indicates strong linkage disequilibrium (r2 0.8 or greater).

Kristina Allen-Brady, et al. Obstet Gynecol. ;118(6):1345-1353.

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