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Results: 3

1.
Figure 1

Figure 1. From: Blood Pressure Loci Identified with a Gene-Centric Array.

Quantile-Quantile Plots of Meta-Analysis Results
Each panel shows common (MAF > 5% shown in blue) and low-frequency (MAF ≤ 5% shown in red) SNPs separately. Shaded regions are 99% probability envelopes for no association, which depend on the number of SNPs and hence are different sizes for common and low-frequency SNPs. The horizontal dashed line indicates our overall study-specific significance threshold p < 8.56 × 10−7.

Toby Johnson, et al. Am J Hum Genet. 2011 December 9;89(6):688-700.
2.
Figure 3

Figure 3. From: Blood Pressure Loci Identified with a Gene-Centric Array.

Heat Plot Showing Percentage of Phenotypic Variance Explained in All Available Data for the Eight SNPs
Numeric values are percentage R2 for continuous traits (DBP, SBP, MAP, PP) and Cox and Snell pseudo-R2 for HTN. Each SNP explains less than 0.1% of phenotypic variance. Stars indicate significance levels adjusting for Meff = 58409 tests: p ≤ 0.05/58,409, ∗∗p ≤ 0.01/58,409, ∗∗∗p ≤ 0.001/58,409.

Toby Johnson, et al. Am J Hum Genet. 2011 December 9;89(6):688-700.
3.
Figure 2

Figure 2. From: Blood Pressure Loci Identified with a Gene-Centric Array.

Regional Association Plots for Eight SNPs that Were p < 8.56 × 10−7 for at Least One Phenotype in an Analysis of Combined Discovery and Follow-Up Data
The top of each plot shows local pairwise LD patterns (r2 = 0 in white; r2 = 1 in red) and a fine-scale recombination rate map (cyan lines). The center of each plot shows association results from the discovery analysis only (to maintain an equal sample size for all points) for the five phenotypes analyzed (DBP in blue, MAP in magenta, PP in green, SBP in red, and HTN in yellow). The bottom of each plot shows positions of transcripts of known genes.

Toby Johnson, et al. Am J Hum Genet. 2011 December 9;89(6):688-700.

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