Results: 5

1.
Fig. 2

Fig. 2. From: Responses of dopaminergic, serotonergic and noradrenergic networks to acute levo-tetrahydropalmatine administration in na?ve rats detected at 9.4 T.

Representative relative voxel time course changes (ΔBOLD %) in regions of NAc (A–C), the IL (D–F), VTA (G–I) and Cl (J– L) after the vehicles, l-THP and naloxone infusions, respectively.

Xiping Liu, et al. Magn Reson Imaging. ;30(2):261-270.
2.
Fig. 1

Fig. 1. From: Responses of dopaminergic, serotonergic and noradrenergic networks to acute levo-tetrahydropalmatine administration in na?ve rats detected at 9.4 T.

Schematic timeline design of three phMRI scans. Distilled water/ l-THP was intravenously infused at the 5th minute into the 60-min scan in Scans I to III, and saline/naloxone was intravenously infused at the 25th minute into the 60-min scan of Scans I and III.

Xiping Liu, et al. Magn Reson Imaging. ;30(2):261-270.
3.
Fig. 4

Fig. 4. From: Responses of dopaminergic, serotonergic and noradrenergic networks to acute levo-tetrahydropalmatine administration in na?ve rats detected at 9.4 T.

Linear correlation of l-THP doses and mean AUC% values. (A) The voxelwise linear regression maps of l-THP doses across the 16 rats. The regional mean AUC% values linearly correlated with l-THP doses in regions of VTA (B) and the HIPP (average for both left and right sides) (C).

Xiping Liu, et al. Magn Reson Imaging. ;30(2):261-270.
4.
Fig. 3

Fig. 3. From: Responses of dopaminergic, serotonergic and noradrenergic networks to acute levo-tetrahydropalmatine administration in na?ve rats detected at 9.4 T.

Dose-dependent activation maps of l-THP from initial l-THP injection compared with the 5-min pre l-THP injection. (A) Activation maps in AUC% with a dose of 5 mg/kg. (B) A dose of 10 mg/kg. (C) A dose of 20 mg/kg. (D) A dose of 40 mg/kg. (E) Anatomy of regional segmentation as the template for image localization processing with MIVA software. (F) Dose-dependent maps obtained with one-way ANOVA test. The color bar shows the z value of the maps (excluding row E). The right side of image is the left side in anatomy, the radiological convention.

Xiping Liu, et al. Magn Reson Imaging. ;30(2):261-270.
5.
Fig. 5

Fig. 5. From: Responses of dopaminergic, serotonergic and noradrenergic networks to acute levo-tetrahydropalmatine administration in na?ve rats detected at 9.4 T.

Pharmacological connectivity maps using four seed regions. (A) VTA connectivity maps. (B) Raphe nucleus maps. (C) BNST maps. (E). PPT maps. The cross-correlation coefficient (CC) values are displayed with the color bar shown on the right (P<.05); green circle indicates seed region location. (D) Common regions of A–C; red represents common areas of VTA and raphe connectivity maps; yellow represents the areas common to VTA and BNST maps; blue represents the areas common to raphe and BNST maps; green represents the areas common to all three maps. (F) Linear correlation between regional AUC% values in VTA and CPu in the dopaminergic connectivity. (G) The raphe nuclei and Thal in the serotonergic connectivity. (H) BNST and Amy related to noradrenergic connectivity.

Xiping Liu, et al. Magn Reson Imaging. ;30(2):261-270.

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