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1.
Figure 2

Figure 2. From: Significance of p53-binding protein 1 nuclear foci in uterine cervical lesions: endogenous DNA double strand breaks and genomic instability during carcinogenesis.

In-situ hybridization signals of high-risk human papillomavirus in cervical lesions. Signal types were classified as diffuse [A, cervical intraepithelial neoplasia (CIN)1], mixed (B, CIN2), or punctate (C, CIN3). Arrows in the inset of B indicate punctate signals.

Katsuya Matsuda, et al. Histopathology. 2011 September;59(3):441-451.
2.
Figure 5

Figure 5. From: Significance of p53-binding protein 1 nuclear foci in uterine cervical lesions: endogenous DNA double strand breaks and genomic instability during carcinogenesis.

Comparison of p53-binding protein 1 (53BP1) (A,C,E,G) and p16INK4a expression (B,D,F,H) in semi-serial sections of cervical lesions. The distribution of 53BP1 nuclear foci was similar to that of p16INK4a overexpression in normal (A,B), cervical intraepithelial neoplasia (CIN1) (C,D), CIN2 (E,F), and squamous cell carcinoma (G,H).

Katsuya Matsuda, et al. Histopathology. 2011 September;59(3):441-451.
3.
Figure 4

Figure 4. From: Significance of p53-binding protein 1 nuclear foci in uterine cervical lesions: endogenous DNA double strand breaks and genomic instability during carcinogenesis.

Dual immunofluorescence for p53-binding protein 1 (53BP1) expression (green) and in-situ hybridization (ISH) signals of high-risk human papillomavirus (red). The distribution of 53BP1 nuclear foci (NF) was the same as that of the punctate type of ISH signal in both cervical intraepithelial neoplasia (CIN)1 with the mixed type (A) and squamous cell carcinoma with punctate type (B) of ISH signal. However, co-localization of 53BP1 NF and the punctate type of ISH signal was very rare. Arrows indicate co-localization of 53BP1 NF and the punctate type of ISH signal.

Katsuya Matsuda, et al. Histopathology. 2011 September;59(3):441-451.
4.
Figure 6

Figure 6. From: Significance of p53-binding protein 1 nuclear foci in uterine cervical lesions: endogenous DNA double strand breaks and genomic instability during carcinogenesis.

Double-label immunofluorescence staining for p53-binding protein 1 (53BP1) (green) and Ki67 expression (red) in cervical lesions. Cervical intraepithelial neoplasia (CIN)1 showed no or a few nuclear foci (NF) of 53BP1 immunoreactivity and little Ki67 nuclear staining, mainly at the basal layer (AC). CIN3 showed several 53BP1 NF that were independent of Ki67 nuclear staining in cancer cells (DF). Squamous cell carcinoma showed nuclei with both 53BP1 NF and Ki67 immunoreactivity (GI), suggesting disruption of the DNA damage response pathway.

Katsuya Matsuda, et al. Histopathology. 2011 September;59(3):441-451.
5.
Figure 3

Figure 3. From: Significance of p53-binding protein 1 nuclear foci in uterine cervical lesions: endogenous DNA double strand breaks and genomic instability during carcinogenesis.

Immunofluorescence for p53-binding protein 1 (53BP1) expression in cervical lesions. Normal cervical epithelium (A) expressed the stable type of staining, with rare, one or two nuclear foci (NF), whereas cervical intraepithelial neoplasia (CIN)1 (B) and CIN2 (C) occasionally expressed three or more NF in dysplastic cells at the basal layer. CIN3 showed several discrete NF (D) with occasional large foci (E) throughout the epithelium. Squamous cell carcinoma (F) showed several discrete NF including large foci.

Katsuya Matsuda, et al. Histopathology. 2011 September;59(3):441-451.
6.
Figure 1

Figure 1. From: Significance of p53-binding protein 1 nuclear foci in uterine cervical lesions: endogenous DNA double strand breaks and genomic instability during carcinogenesis.

A, four types of p53-binding protein 1 (53BP1) expression found in HeLa cells: (1) stable type – faint and diffuse nuclear staining; (2) low DNA damage response (DDR) type – one or two discrete nuclear foci (NF); (3) high DDR type – three or more discrete NF; and (4) large NF type – discrete NF that are larger than 1.0 μm. B, measurements of the size of NF in a cell by use of a High Standard All-in-One Fluorescence Microscope (Biorevo BZ-9000; Keyence Japan). 1, 1.01 μm; 2, 1.05 μm; 3, 0.53 μm.

Katsuya Matsuda, et al. Histopathology. 2011 September;59(3):441-451.

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