Figure

Figure. Physical Impairment domain scores worsen over time. From: Quantifying physical decline in juvenile neuronal ceroid lipofuscinosis (Batten disease).

(A) Physical Impairment scores at the most recent time of testing for all subjects are shown. The fitted line of predicted values (green dashed line) is based on ordinary linear regression analysis for the entire cohort using the most recent Physical Impairment score with age as the only independent variable. The colored labels indicate the subject's CLN3 genotype (CLN3 deletion homozygotes, filled blue diamond, and other CLN3 genotypes, filled red circle). Subject A is described in the text. (B) Physical Impairment scores of the subset who are homozygous for the common CLN3 deletion (the most common genotype seen). When subjects participated for multiple evaluations, their scores are marked by connected hollow blue diamonds. Those seen for a single visit are marked by a filled blue diamond. The fitted regression line (blue) with 95% confidence interval (CI) reflects the regression estimates for this subset only. The dashed green line is included to show the fitted regression for the entire cohort, discussed in A. (C) Physical Impairment scores of those with other CLN3 genotypes (noncommon deletion homozygotes.) When subjects participated for multiple evaluations, their scores are marked by connected hollow red circles, and those seen for a single visit are marked with a filled red circle. The fitted regression line with 95% CI reflects the regression estimates for this subset only. Subject A is described in the text.

J.M. Kwon, et al. Neurology. 2011 November 15;77(20):1801-1807.

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