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1.
Figure 2

Figure 2. From: Inhibition of PKC?/? with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury.

Western blot analysis of calcium handling proteins, myofilament proteins, and PKCα/β/γ for the native protein or for the indicated specific phosphorylation site from pig hearts after 3 months of ruboxistaurin treatment or no treatment after myocardial infarction injury. One non-infarcted control is shown. The indicated proteins or phosphoproteins were analyzed from pieces of anterior or inferior portions of the left ventricle. The “-P” designation represents specialized gel electrophoresis conditions that separate proteins with differential phosphorylation.

Dennis Ladage, et al. Circ Res. ;109(12):1396-1400.
2.
Figure 1

Figure 1. From: Inhibition of PKC?/? with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury.

Ruboxistaurin attenuates heart failure in pigs post MI. A, Millar catheter-based analysis of heart rate and B, contractility in vehicle or ruboxistaurin treated (10 mg/kg/day) pigs subjected to MI injury at the indicated times after injury (days or months). #P<0.05 versus 0 time point. *P<0.05 versus vehicle treated pigs at 3 months. C, left ventricular ejection fraction measured by ventriculography in vehicle or ruboxistaurin treated pigs after MI for the indicated periods of time (days or months). *P<0.05 versus vehicle at 3 months. D, Cardiac output measured with a Swan Ganz catheter in vehicle or ruboxistaurin treated pigs after MI for the indicated periods of time. *P<0.05 versus vehicle at 3 months. E, Quantitation of scar size after TTC staining to show area of injury between the 2 groups. N.S.=not significantly different. F, Pig heart slices after MI injury stained with TTC (white area is not stained by TTC and represents the area of infraction).

Dennis Ladage, et al. Circ Res. ;109(12):1396-1400.

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