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Results: 5

1.
Figure 5

Figure 5. From: Detecting gene-gene interactions in prostate disease in African American men.

Expression of ABCD3 in panel of paired prostate cancer cell lines. (A) qRT-PCR of non-malignant African American RC-77N/E was compared to malignant RC-77T/E cells, DU-145 was compared to DU-145 WT (EGFR overexpressing), LnCaP was compared to C4-2B, and all samples were compared to African American MDA-PC-2b cells. Results shown is representative of experiments performed in triplicate.

R Renee Reams, et al. Infect Agent Cancer. 2011;6(Suppl 2):S1-S1.
2.
Figure 4

Figure 4. From: Detecting gene-gene interactions in prostate disease in African American men.

Ingenuity Pathway Analysis identified NFKB as the Top Network signaling Hub where the shaded shapes indicate the candidate genes from the present study. Dotted line indicates an indirect cellular interaction and solid lines indicate a physical interaction (.I.e. binding) between genes. Molecules are identified with their HUGO symbol. Different shapes (diamond, circle or rectangles) of the nodes represent functional classification of the genes shown.

R Renee Reams, et al. Infect Agent Cancer. 2011;6(Suppl 2):S1-S1.
3.
Figure 3

Figure 3. From: Detecting gene-gene interactions in prostate disease in African American men.

Ingenuity Pathway Analysis identified MapK as second Top network signaling Hub where the shaded shapes indicate the candidate genes from current study. Dotted line indicates an indirect cellular interaction and solid lines indicate a physical interaction between genes. Molecules are identified with their HUGO symbol. Different shapes (diamond, circle or rectangles) of the nodes represent functional classification of the genes shown.

R Renee Reams, et al. Infect Agent Cancer. 2011;6(Suppl 2):S1-S1.
4.
Figure 2

Figure 2. From: Detecting gene-gene interactions in prostate disease in African American men.

Ingenuity Pathway Analysis identified ERK as the Top network signaling Hub where the shaded shapes indicate the candidate genes from the present study. RANGAP1 is found in the ERK pathway. Dotted line indicates an indirect cellular interaction and solid lines indicate a physical interaction between genes. Genes are identified with their HUGO symbol. Dotted line indicates an indirect cellular interaction and solid lines indicate a physical interaction (acts on or inhibits) between genes. Different shapes (diamond, circle or rectangles) of the nodes represent functional classification of the genes.

R Renee Reams, et al. Infect Agent Cancer. 2011;6(Suppl 2):S1-S1.
5.
Figure 1

Figure 1. From: Detecting gene-gene interactions in prostate disease in African American men.

GWAS Plot of Gene-Gene Associations illustrates p-values (shown on y-axis) of SNP for gene variants found on chromosomes 1-22(x-axis). The x-axis shows Chromosomes 1 thru 22. Each dot represents gene variants or SNPs. In the circled dots to the extreme left positioned above Chromosome 1 (x-axis), the dot with the highest p-value represents an ABCD3 gene variant with a defined rs# that is strongly interacting with RANGAP1 to influence CaP tumors in African American. All of the dots in the circle reveal an association of SNPs surrounding ABCD3 gene with basal gene expression of RanGAP1. This variation in gene expression RanGAP1 might be influenced by the SNPs in ABCD3 Similarly in the circled points to the far right, positioned above chromosome 12 ( x-axis), the dot with the highest p-value represents the TMTC2 gene variant with a defined rs#, that strongly interacts with STXBP2. All the dots in the circle represent an association of SNPs surrounding TMTC2 gene with basal gene expression of STXBP2.

R Renee Reams, et al. Infect Agent Cancer. 2011;6(Suppl 2):S1-S1.

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