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Results: 4

1.
Figure 1.

Figure 1. From: Single Immunization With a Monovalent Vesicular Stomatitis Virus-Based Vaccine Protects Nonhuman Primates Against Heterologous Challenge With Bundibugyo ebolavirus.

Outcomes of cynomolgus macaques challenged with Bundibugyo ebolavirus (BEBOV). A, Kaplan-Meier survival curve for cynomolgus macaques vaccinated with sesicular stomatitis virus, lacking its glycoprotein gene (VSVΔG) containing the Zaire ebolavirus glycoprotein (VSVΔG-ZEBOVgp), VSVΔG containing the Côte d'Ivoire ebolavirus glycoprotein (VSVΔG-CIEBOVgp), or Dulbecco's modified Eagle medium (DMEM) and subsequently challenged with BEBOV on day 28 after vaccination. B, Mean clinical score following BEBOV challenge.

Darryl Falzarano, et al. J Infect Dis. 2011 November 1;204(Suppl 3):S1082-S1089.
2.
Figure 2.

Figure 2. From: Single Immunization With a Monovalent Vesicular Stomatitis Virus-Based Vaccine Protects Nonhuman Primates Against Heterologous Challenge With Bundibugyo ebolavirus.

Clinical blood chemistry, blood counts, and coagulation analysis of cynomolgus macaques challenged with Bundibugyo ebolavirus (BEBOV). Whole blood, serum, and plasma samples were collected at the indicated time points and the mean levels of (A) platelets, (B) alanine aminotransferase (ALT), (C) albumin, (D) blood urea nitrogen (BUN), (E) prothrombin time (PT), and (F) activated partial thromboplastin time (aPTT) were determined.

Darryl Falzarano, et al. J Infect Dis. 2011 November 1;204(Suppl 3):S1082-S1089.
3.
Figure 3.

Figure 3. From: Single Immunization With a Monovalent Vesicular Stomatitis Virus-Based Vaccine Protects Nonhuman Primates Against Heterologous Challenge With Bundibugyo ebolavirus.

Genome copies of Bundibugyo ebolavirus (BEBOV) in samples from BEBOV-challenged cynomolgus macaques. Blood (A), rectal (B), and throat (C) swab samples were obtained at the time point indicated, total RNA was extracted, quantitative real-time reverse-transcription polymerase chain reaction was performed, and genome copies were calculated. Survivors are indicated by a closed box, whereas animals that were euthanized due to clinical score are indicated by an open box. Data points along the x-axis represent surviving animals that did not have detectable viremia. (VSVΔG-ZEBOVgp), vesicular stomatitis virus lacking its glycoprotein gene, containing the Zaire ebolavirus glycoprotein; (VSVΔG-CIEBOVgp), vesicular stomatitis virus lacking its glycoprotein gene, containing the Côte d'Ivoire ebolavirus glycoprotein; DMEM, Dulbecco's modified Eagle medium.

Darryl Falzarano, et al. J Infect Dis. 2011 November 1;204(Suppl 3):S1082-S1089.
4.
Figure 4.

Figure 4. From: Single Immunization With a Monovalent Vesicular Stomatitis Virus-Based Vaccine Protects Nonhuman Primates Against Heterologous Challenge With Bundibugyo ebolavirus.

Antibody response in cynomolgus macaques following vesicular stomatitis virus (VSV)–based vaccination and Bundibugyo ebolavirus (BEBOV) infection. The reciprocal endpoint immunoglobulin (Ig) G titer from serum samples was determined against (A) the Ebola virus glycoprotein (GP) delivered by the vaccine (Zaire ebolavirus [ZEBOV] GP for animals vaccinated with vesicular stomatitis virus lacking its glycoprotein [VSVΔG] containing ZEBOVgp [VSVΔG-ZEBOVgp] or VSVΔG containing Côte d'Ivoire ebolavirus (CIEBOV) GP [VSVΔG-CIEBOVgp] and Dulbecco's modified Eagle medium [DMEM]-treated animals) at 3 days after BEBOV infection and (B) BEBOV GP at 3 days after BEBOV infection and on the day of euthanasia (Euth). Survivors are indicated by a closed box, whereas animals that were euthanized due to clinical score are indicated by an open box. No titer was detected in DMEM-vaccinated animals against ZEBOV GP (data not shown).

Darryl Falzarano, et al. J Infect Dis. 2011 November 1;204(Suppl 3):S1082-S1089.

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