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Figure 1

Figure 1. From: Effects of Hypoperfusion in Alzheimer's Disease.

Schematic figure of a perfusion model of chronic brain hypoperfusion (CBH) and micro- and macro-structural changes leading to behavioral deficits and cognitive impairment. The triangle represents a vasculature compromised in varying degrees with accompanying hemodynamic changes leading to CBH. Normal-aging, followed by TIA and MCI, followed by stroke, VaD, and AD in a graded fashion influence neural network reorganization in terms of increasing degree of vascular/perfusion changes as well as structural and functional mapping changes. These changes ultimately influence neuropsychological measures. AD, Alzheimer’s disease; MCI, mild cognitive impairment; TIA, transient ischemic attack; VaD, vascular dementia.

Benjamin P. Austin, et al. J Alzheimers Dis. ;26(Suppl 3):123-133.

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