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Results: 13

1.
FIGURE 8.

FIGURE 8. From: Structure and Function of Papiliocin with Antimicrobial and Anti-inflammatory Activities Isolated from the Swallowtail Butterfly, Papilio xuthus.

Enhancement of the intensity of FITC-labeled LPS as a function of papiliocin concentration. AU, absorbance unit.

Jin-Kyoung Kim, et al. J Biol Chem. 2011 December 2;286(48):41296-41311.
2.
FIGURE 3.

FIGURE 3. From: Structure and Function of Papiliocin with Antimicrobial and Anti-inflammatory Activities Isolated from the Swallowtail Butterfly, Papilio xuthus.

A, inhibition of nitrite production by papiliocin, cecropin A, and LL-37 in LPS-stimulated RAW264.7 cells. B, inhibition of TNF-α production by papiliocin and LL-37 in LPS-stimulated RAW264.7 cells. C, inhibition of MIP-2 production by papiliocin and LL-37 in LPS-stimulated RAW264.7 cells.

Jin-Kyoung Kim, et al. J Biol Chem. 2011 December 2;286(48):41296-41311.
3.
FIGURE 1.

FIGURE 1. From: Structure and Function of Papiliocin with Antimicrobial and Anti-inflammatory Activities Isolated from the Swallowtail Butterfly, Papilio xuthus.

Helical-wheel diagram of papiliocin. A, N-terminal helix region from Arg1 to Lys21. B, C-terminal helix region from Ala25 to Lys37. The hydrophobic residues are indicated in gray, and the hydrophilic residues are shown in black.

Jin-Kyoung Kim, et al. J Biol Chem. 2011 December 2;286(48):41296-41311.
4.
FIGURE 2.

FIGURE 2. From: Structure and Function of Papiliocin with Antimicrobial and Anti-inflammatory Activities Isolated from the Swallowtail Butterfly, Papilio xuthus.

A, dose-response curve for the hemolytic activity of papiliocin toward human erythrocytes. B, dose-response curves for the cytotoxicity of papiliocin (●), melittin (○), and LL-37 (▾) toward macrophage-derived RAW264.7 cells.

Jin-Kyoung Kim, et al. J Biol Chem. 2011 December 2;286(48):41296-41311.
5.
FIGURE 5.

FIGURE 5. From: Structure and Function of Papiliocin with Antimicrobial and Anti-inflammatory Activities Isolated from the Swallowtail Butterfly, Papilio xuthus.

A, effects of papiliocin on TLR4. B, effects of papiliocin on nuclear NF-κB. TLR4 and NF-κB protein levels were determined by Western blot analysis using specific antibodies.

Jin-Kyoung Kim, et al. J Biol Chem. 2011 December 2;286(48):41296-41311.
6.
FIGURE 10.

FIGURE 10. From: Structure and Function of Papiliocin with Antimicrobial and Anti-inflammatory Activities Isolated from the Swallowtail Butterfly, Papilio xuthus.

NOESY spectra of the NH-NH region of papiliocin in 300 mm DPC micelles at pH 5.9 and 303 K (mixing time, 250 ms).

Jin-Kyoung Kim, et al. J Biol Chem. 2011 December 2;286(48):41296-41311.
7.
FIGURE 11.

FIGURE 11. From: Structure and Function of Papiliocin with Antimicrobial and Anti-inflammatory Activities Isolated from the Swallowtail Butterfly, Papilio xuthus.

Summary of NOE connectivities and CαH chemical shift indices for papiliocin in 300 mm DPC micelles. The thickness of the line for the NOEs reflects the intensity of the NOE connectivities.

Jin-Kyoung Kim, et al. J Biol Chem. 2011 December 2;286(48):41296-41311.
8.
FIGURE 4.

FIGURE 4. From: Structure and Function of Papiliocin with Antimicrobial and Anti-inflammatory Activities Isolated from the Swallowtail Butterfly, Papilio xuthus.

Effect of papiliocin on LPS-induced expression of inflammatory cytokines in RAW264.7 cells. Total RNA was analyzed for the expression of IL-1β, IL-6, MIP-1, MIP-2, TNF-α, iNOS, and GAPDH (loading control) mRNA by RT-PCR.

Jin-Kyoung Kim, et al. J Biol Chem. 2011 December 2;286(48):41296-41311.
9.
FIGURE 6.

FIGURE 6. From: Structure and Function of Papiliocin with Antimicrobial and Anti-inflammatory Activities Isolated from the Swallowtail Butterfly, Papilio xuthus.

Dose-response curves of calcein leakage from EYPC/EYPG (7:3, w/w) (A) and EYPC/CH LUVs (10:1, w/w) (B) induced by papiliocin. Calcein leakage was measured 2 min after adding papiliocin. The lipid concentration used in the leakage experiments was 64 μm.

Jin-Kyoung Kim, et al. J Biol Chem. 2011 December 2;286(48):41296-41311.
10.
FIGURE 9.

FIGURE 9. From: Structure and Function of Papiliocin with Antimicrobial and Anti-inflammatory Activities Isolated from the Swallowtail Butterfly, Papilio xuthus.

CD spectra of peptides (50 μm, pH 4.1) in H2O, a 15% HFIP/water solution, 100 mm SDS micelles, 50 mm DPC micelles, and 100 μm LPS.

Jin-Kyoung Kim, et al. J Biol Chem. 2011 December 2;286(48):41296-41311.
11.
FIGURE 13.

FIGURE 13. From: Structure and Function of Papiliocin with Antimicrobial and Anti-inflammatory Activities Isolated from the Swallowtail Butterfly, Papilio xuthus.

STD-NMR results showing the interaction between 0.5 mm papiliocin and 0.015 mm LPS. A, 1H NMR spectra of papiliocin; B, its STD effects. Spectral differences primarily constituted resonances belonging to peptide protons bound to LPS.

Jin-Kyoung Kim, et al. J Biol Chem. 2011 December 2;286(48):41296-41311.
12.
FIGURE 7.

FIGURE 7. From: Structure and Function of Papiliocin with Antimicrobial and Anti-inflammatory Activities Isolated from the Swallowtail Butterfly, Papilio xuthus.

Stern-Volmer plots of acrylamide quenching of tryptophan fluorescence of papiliocin (A and C) and melittin (B and D) in the presence of sodium phosphate buffer, pH 6.0 (●), 8.0 μm LPS (○), 1.5 mm DPC (▾), Tris buffer, pH 7.4 (▿), EYPC/EYPG (7:3, w/w) SUV (■), and EYPC/CH SUVs (10:1, w/w) (□).

Jin-Kyoung Kim, et al. J Biol Chem. 2011 December 2;286(48):41296-41311.
13.
FIGURE 12.

FIGURE 12. From: Structure and Function of Papiliocin with Antimicrobial and Anti-inflammatory Activities Isolated from the Swallowtail Butterfly, Papilio xuthus.

A, superpositions of the 20 lowest energy structures calculated from the NMR data for papiliocin in 300 mm DPC micelles. The backbone atoms of residues Lys3 to Lys21 are superimposed. B, ribbon diagram of the average structure of papiliocin in 300 mm DPC micelles. The hydrophobic residues are indicated in red, and the hydrophilic residues are shown in blue. C, head-on view of the amphipathic N-terminal helix from Lys3 to Lys21 of papiliocin.

Jin-Kyoung Kim, et al. J Biol Chem. 2011 December 2;286(48):41296-41311.

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