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1.

Figure 2. From: Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function.

Manhattan plots of association results for (a) FEV1/FVC and (b) FEV1. Manhattan plots ordered by chromosome position. SNPs for which −log10P>5 are indicated in red. Novel regions which reached genome-wide significance after Stage 1 + Stage 2 are labelled.

María Soler Artigas, et al. Nat Genet. ;43(11):1082-1090.
2.
Figure 1

Figure 1. From: Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function.

Study design. A total of 34 SNPs showing novel evidence of association (P<3×10−6) with FEV1 and/or FEV1/FVC in a meta-analysis of the Stage 1 studies were followed up in Stage 2. Studies with a combined total of 24,737 individuals undertook genotyping and association testing of the top 10 SNPs. Seven studies (*) with a combined total of 11,275 individuals had genome-wide association data and provided results for up to 34 SNPs. #GS:SFHS undertook genotyping on a 32-SNP multiplex genotyping platform and so included the 32 top ranking SNPs (including proxies and both SNPs from regions which showed association with both FEV1 and FEV1/FVC). This assay failed for one SNP (rs3769124) which was subsequently replaced with the 33rd SNP (rs4762767). SNP rs2284746 was excluded due to poor clustering. Although rs3743563 was chosen as proxy for rs12447804 which had N effective <80% in the Stage 1 meta-analysis, BHS2 were unable to genotype rs3743563 and so undertook genotyping for rs12447804 instead. See Table 1 for definitions of abbreviations.

María Soler Artigas, et al. Nat Genet. ;43(11):1082-1090.

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