Results: 4

1.
Fig. 2.

Fig. 2. From: Model-Based Approach for Optimization of Atazanavir Dose Recommendations for HIV-Infected Pediatric Patients .

Effects of continuous covariates on ATV PK parameters (CL/F, V/F, and ka). The covariate effect (95% CI) at the 5th and 95th percentiles of the covariate is represented by the end of the horizontal box (horizontal line). The open and shaded areas of the box represent the range of covariate effects from the median to the 5th and 95th percentiles, respectively, of the covariate.

Ying Hong, et al. Antimicrob Agents Chemother. 2011 December;55(12):5746-5752.
2.
Fig. 1.

Fig. 1. From: Model-Based Approach for Optimization of Atazanavir Dose Recommendations for HIV-Infected Pediatric Patients .

Effects of categorical covariates on ATV PK parameters (CL/F and Frel). An open circle shows the estimated covariate effect compared to the reference. Error bars show the 95% confidence interval (95% CI) for the covariate effect. The covariate effect for the reference is considered 100% (vertical solid line), and dashed vertical lines show 80% and 120% of the reference effect.

Ying Hong, et al. Antimicrob Agents Chemother. 2011 December;55(12):5746-5752.
3.
Fig. 3.

Fig. 3. From: Model-Based Approach for Optimization of Atazanavir Dose Recommendations for HIV-Infected Pediatric Patients .

Posterior predictive check of ATV population PK model. The observed geometric means of week 1 Cmin, Cmax, and AUC in pediatric and adult patients (solid circles) are compared with the medians (open circles) and 5th and 95th percentile ranges (horizontal bars) of the geometric means for exposures calculated from 1,000 simulations.

Ying Hong, et al. Antimicrob Agents Chemother. 2011 December;55(12):5746-5752.
4.
Fig. 4.

Fig. 4. From: Model-Based Approach for Optimization of Atazanavir Dose Recommendations for HIV-Infected Pediatric Patients .

Geometric means of ATV exposures (AUC, Cmax, and Cmin). Model-based simulations were conducted to evaluate a comprehensive set of weight-tiered ATV capsule doses for pediatric patients weighing ≥15 kg to determine optimal RTV-boosted ATV capsule dose recommendations for pediatric patients. The proposed, weight-based ATV doses are labeled by crosses. The vertical dashed line in each panel represents the respective target adult exposure (80% and 125% of adult GM AUC, 150% of adult GM Cmax, and 75% of adult GM Cmin).

Ying Hong, et al. Antimicrob Agents Chemother. 2011 December;55(12):5746-5752.

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