Results: 4

1.
Figure 4

Figure 4. From: Identification of the putative intestinal stem cell marker DCAMKL-1 in Barrett's Esophagus and Esophageal Adenocarcinoma.

DCAMKL-1 is overexpressed in BE. (A) Increased DCAMKL-1 mRNA expression in BE compared to normal. (B–C) Increased Msi-1 (B) and LGR5 (C) mRNA expression in BE compared to normal. Values in the bar graphs are given as average ± SEM, and asterisks denote statistically significant differences (* p<0.01) compared to normal.

Kenneth J. Vega, et al. J Gastroenterol Hepatol. ;27(4):773-780.
2.
Figure 2

Figure 2. From: Identification of the putative intestinal stem cell marker DCAMKL-1 in Barrett's Esophagus and Esophageal Adenocarcinoma.

Immunohistochemical expression of DCAMKL-1 in endoscopically obtained, histologically confirmed squamous esophageal mucosa. (A) Minimal DCAMKL-1 expression in normal squamous epithelium. (B) Increased DCAMKL-1 expression in the squamous cells of BE without dysplasia; Progressive increase of perinuclear DCAMKL-1 expression in reactive, irregular cells of BE with dysplasia (C) and in dysplastic cells of Adenocarcinoma/EAC (D). Brown indicates cells positive for DCAMKL-1.

Kenneth J. Vega, et al. J Gastroenterol Hepatol. ;27(4):773-780.
3.
Figure 1

Figure 1. From: Identification of the putative intestinal stem cell marker DCAMKL-1 in Barrett's Esophagus and Esophageal Adenocarcinoma.

Immunohistochemical expression of DCAMKL-1 in Normal, BE without dysplasia, BE with dysplasia and Adenocarcinoma/EAC. (A) Minimal DCAMKL-1 epithelial staining in normal squamous epithelium. (B–D) Increased expression of DCAMKL-1 in stroma of biopsies of BE with no dysplasia (B) and BE with dysplasia (C) as well as Adenocarcinoma/EAC in situ (D). Brown indicates cells positive for DCAMKL-1. (E–F) Immunohistochemical scoring of DCAMKL-1 in epithelium (E) and stroma (F) of various tissues as indicated. Values in the bar graphs are given as average ± SEM, and asterisks denote statistically significant differences (* p<0.05 = BE with dysplasia compared to Normal; ** p<0.05 = Adenocarcinoma compared to Normal).

Kenneth J. Vega, et al. J Gastroenterol Hepatol. ;27(4):773-780.
4.
Figure 3

Figure 3. From: Identification of the putative intestinal stem cell marker DCAMKL-1 in Barrett's Esophagus and Esophageal Adenocarcinoma.

Immunohistochemical expression of DCAMKL-1 within endoscopically obtained, histologically confirmed glandular epithelium, BE without dysplasia, BE with dysplasia and Adenocarcinoma/EAC. (A) Scattered individual epithelial cells were positive for DCAMKL-1 in normal patients without BE. (B–D) The appearance of DCAMKL-1 expression in columnar epithelial cells in BE without dysplasia (B), increased expression of DCAMKL-1 in the columnar epithelia and the appearance of stromal cells positive for DCAMKL-1 in BE with dysplasia (C) overall increase in the number and intensity of DCAMKL-1 expression in both columnar and stromal compartments in Adenocarcinoma/EAC. (D). Minimal DCAMKL-1 immunostaining is observed in endothelial cells in patients with BE without dysplasia (arrows indicates endothelial cells) (E). Increased DCAMKL-1 staining is observed endothelial cells in BE with dysplasia (F). Brown indicates cells positive for DCAMKL-1 (arrows).

Kenneth J. Vega, et al. J Gastroenterol Hepatol. ;27(4):773-780.

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