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2.
Figure 2

Figure 2. Adjusted curves grouped by randomization to enalapril or placebo and subsequent early worsening renal function status in patients who did not discontinue or dose reduce the study drug in proximity to worsening renal function. From: Prognostic Importance of Early Worsening Renal Function Following Initiation of Angiotensin Converting Enzyme Inhibitor Therapy in Patients with Cardiac Dysfunction.

WRF: Worsening renal function. Early WRF defined as a 20% reduction in glomerular filtration rate from baseline to 14 days post randomization. Covariates adjusted for: age, race, ejection fraction, heart rate, diastolic blood pressure, NYHA class, serum sodium, eGFR, history of diabetes, hypertension, stroke or myocardial infarction, loop diuretic, potassium sparing diuretic, digoxin, and beta blocker use.

Jeffrey M. Testani, et al. Circ Heart Fail. ;4(6):685-691.

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