We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 5

1.
FIG 2

FIG 2 . From: H5N1 Influenza Virus Pathogenesis in Genetically Diverse Mice Is Mediated at the Level of Viral Load.

The hematopoietic component does not confer resistance in susceptible strains. Chimeric DBA/2S mice containing bone marrow from resistant (C57BL/6R or BALB/cR) or susceptible (DBA/2S) mice were inoculated with 104 EID50 (A) or 103 EID50 (B) of A/Hong Kong/213/03 virus and monitored for morbidity and mortality for 21 days.

Adrianus C. M. Boon, et al. mBio. 2011 Sep-Oct;2(5):e00171-11.
2.
FIG 1

FIG 1 . From: H5N1 Influenza Virus Pathogenesis in Genetically Diverse Mice Is Mediated at the Level of Viral Load.

Pathogenic profile of 21 inbred mouse strains inoculated with highly pathogenic H5N1 influenza A virus. The 50% mouse lethal dose (MLD50) of A/Hong Kong/213/03 virus is shown. A dose of 104 EID50 (dotted line) was set to distinguish influenza virus-resistant from influenza virus-susceptible mouse strains and used throughout the work to assess biological parameters associated with severity of disease and mortality.

Adrianus C. M. Boon, et al. mBio. 2011 Sep-Oct;2(5):e00171-11.
3.
FIG 4

FIG 4 . From: H5N1 Influenza Virus Pathogenesis in Genetically Diverse Mice Is Mediated at the Level of Viral Load.

Elevated production of proinflammatory mediators in susceptible mouse strains after inoculation with H5N1 virus. Cytokine concentrations (pg/ml) were measured in homogenized lung tissues of DBA/2S, 129/SvImS, A/JS, SMR, C57BL/6R, and BALB/cR mice 3 days after inoculation with highly pathogenic A/Hong Kong/213/03 H5N1 virus. Bars represent mean cytokine production levels + SEMs. Statistical significance (P < 0.01) between the six mouse strains is represented by letters above each column, with different letters signifying distinct statistical groups.

Adrianus C. M. Boon, et al. mBio. 2011 Sep-Oct;2(5):e00171-11.
4.
FIG 3

FIG 3 . From: H5N1 Influenza Virus Pathogenesis in Genetically Diverse Mice Is Mediated at the Level of Viral Load.

Principal component analysis identifies the gene expression profile associated with severity of H5N1 virus disease. Principal component analysis using ~26,000 probes in lung tissue RNA of DBA/2S, 129/SvImS, A/JS, SMR, C57BL/6R, and BALB/cR mice prior to infection (control) and on days 1, 3, and 7 after inoculation with 104 EID50 of A/Hong Kong/213/03. Each dot represents the RNA expression profile of a single mouse. Colored circles indicate the three clusters of highly susceptible (red), intermediate susceptible (blue), and resistant (green) mouse strains. The x, y, and z axes correspond to principal components 1, 2, and 3, respectively.

Adrianus C. M. Boon, et al. mBio. 2011 Sep-Oct;2(5):e00171-11.
5.
FIG 5

FIG 5 . From: H5N1 Influenza Virus Pathogenesis in Genetically Diverse Mice Is Mediated at the Level of Viral Load.

Viral load determines proinflammatory cytokine production in genetically diverse mice. (A) Higher viral load (∆∆CT value) in susceptible mouse strains (DBA/2S, 129SvImS, and A/JS) than in the resistant strains C57BL/6R and BALB/cR 1 and 3 days postinoculation (dpi) with 104 EID50 of H5N1 virus. Dots indicate individual mice, and the average values + SEMs are indicated by the solid bars. (B) Resistant mouse strains (SMR, C57BL/6R, and BALB/cR) more effectively limit virus replication between 1 and 3 dpi than do susceptible strains. Bars represent average fold increases in viral RNA + SEMs. (C) Higher viral load in susceptible mouse strains plus SMR triggers an increase in production of proinflammatory mediators CCL2, IFN-β1, and TNF-α at 3 dpi (gray bars; P < 0.01) but not at 1 dpi (black bars; P > 0.05). Bars represent average ∆∆CT values + SEMs.

Adrianus C. M. Boon, et al. mBio. 2011 Sep-Oct;2(5):e00171-11.

Supplemental Content

Recent activity

Your browsing activity is temporarily unavailable.

Write to the Help Desk