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1.
Figure 3

Figure 3. From: Corticotropin-releasing factor receptor 1 antagonist alters regional activation and effective connectivity in an emotional-arousal circuit during expectation of abdominal pain.

Error plot showing standard mean errors (±1 SE) for beta contrasts (Threat – Safe) following placebo (PLA) versus a 20 mg GW876008 or 200 mg dose of GW876008 for the left (L) hypothalamus in IBS patients and healthy controls (HCs) during pain expectation.

Catherine S. Hubbard, et al. J Neurosci. ;31(35):12491-12500.
2.
Figure 4

Figure 4. From: Corticotropin-releasing factor receptor 1 antagonist alters regional activation and effective connectivity in an emotional-arousal circuit during expectation of abdominal pain.

Error plot showing standard mean errors (±1 SE) for beta contrasts (Threat – Safe) following placebo (PLA) versus a 20 mg GW876008 or 200 mg dose of GW876008 for left locus coeruleus complex (L LCC) in IBS patients and healthy controls (HCs) during pain expectation.

Catherine S. Hubbard, et al. J Neurosci. ;31(35):12491-12500.
3.
Figure 2

Figure 2. From: Corticotropin-releasing factor receptor 1 antagonist alters regional activation and effective connectivity in an emotional-arousal circuit during expectation of abdominal pain.

Path diagram from structural equation modeling analysis used for testing effective connectivity of network nodes of an emotional-arousal circuit involving left hemispheric structures. Nodes of the circuit are illustrated along with MNI coordinates (x, y, z). Abbreviations: AMYG—amygdala, aINS—anterior insula, HPC—hippocampus, HT—hypothalamus, LCC—locus coeruleus complex, OFC—orbitomedial prefrontal cortex, aMCC—anterior midcingulate cortex, sgACC—subgenual anterior cingulate cortex.

Catherine S. Hubbard, et al. J Neurosci. ;31(35):12491-12500.
4.
Figure 6

Figure 6. From: Corticotropin-releasing factor receptor 1 antagonist alters regional activation and effective connectivity in an emotional-arousal circuit during expectation of abdominal pain.

Scatterplots illustrating the distribution of parameter estimates for BOLD signal activity in the left (A) hypothalamus and (B) locus coeruleus complex in IBS patients and healthy controls (HCs) across the three different treatment conditions (placebo, PLA; 20 mg GW876008; 200 mg GW876008). Gray lines indicate parameter estimate means within group for each treatment condition.

Catherine S. Hubbard, et al. J Neurosci. ;31(35):12491-12500.
5.
Figure 5

Figure 5. From: Corticotropin-releasing factor receptor 1 antagonist alters regional activation and effective connectivity in an emotional-arousal circuit during expectation of abdominal pain.

Path coefficients for the effective connectivity analysis of an ‘emotional-arousal circuit’ during expectation of abdominal pain following placebo (PLA) versus high dose of the CRF1 antagonist (200 mg GW876008) in healthy controls (HCs) and IBS patients. Parameter estimates that were significantly different are represented by green arrows (light gray arrows in print version) whereas those that were not significantly different are represented by dark gray arrows. Abbreviations: AMYG—amygdala, aINS—anterior insula, HPC—hippocampus, HT—hypothalamus, LCC—locus coeruleus complex, OFC—orbitomedial prefrontal cortex, aMCC—anterior midcingulate cortex, sgACC—subgenual anterior cingulate cortex.

Catherine S. Hubbard, et al. J Neurosci. ;31(35):12491-12500.
6.
Figure 1

Figure 1. From: Corticotropin-releasing factor receptor 1 antagonist alters regional activation and effective connectivity in an emotional-arousal circuit during expectation of abdominal pain.

Schematic illustrating experimental design (top panel) and the abdominal pain expectation protocol (bottom panel). Top panel: Each subject received a single acute oral dose of either placebo (PLA; 0 mg), 20 mg GW876008 or 200 mg GW876008 in a randomized, double-blind manner across three separate study treatment (TX) visits (visit day 3, 4, and 5) each separated by approximately one month. Bottom panel: shows the safe (S; blue) and threat (T; red) trials (30 s trials with 15 s intertrial intervals) for a single MRI run for the abdominal pain expectation paradigm.

Catherine S. Hubbard, et al. J Neurosci. ;31(35):12491-12500.

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