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Results: 2

1.
Figure 1

Figure 1. Replicated SNPs for binary traits.. From: Efficient Replication of over 180 Genetic Associations with Self-Reported Medical Data.

Our log ORs and 95% confidence intervals are shown as black circles and lines. Published ORs are shown as blue Xs.

Joyce Y. Tung, et al. PLoS One. 2011;6(8):e23473.
2.
Figure 2

Figure 2. Success rate (versus total power) by disease class.. From: Efficient Replication of over 180 Genetic Associations with Self-Reported Medical Data.

Replications = number of associations we successfully replicated. Expected = number of associations we expected to replicate. Attempts = number of associations we attempted to replicate. The blue dot represents our success ratio (number of successful replications divided by number of expected replications). The black line represents the 95% prediction interval for the success ratio. The nine associations that we had high power to detect but had known conflicting data were not included in this figure (see text and Table 1). Conditions assigned to each class (also see Methods S1): Asthma: childhood asthma; Autoimmune: Crohn's disease, inflammatory bowel disease, lupus, multiple sclerosis, psoriasis, type 1 diabetes, ulcerative colitis; Cancer: basal cell carcinoma, bladder cancer, breast cancer, colorectal cancer, prostate cancer, lung cancer, melanoma, pancreatic cancer, scleroderma, testicular cancer, thyroid cancer; Celiac: celiac disease; Diabetes: type 2 diabetes; Heart: blood clots, coronary artery disease, heart attack; Pigment/Hair: eye color, freckling, hair color, red hair color, male pattern baldness; Neuro: Alzheimer's disease, autism, Parkinson's disease; Other: chronic obstructive pulmonary disease, kidney stones, stroke, osteoarthritis; Psychiatric: alcohol abuse, bipolar disorder, schizophrenia.

Joyce Y. Tung, et al. PLoS One. 2011;6(8):e23473.

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