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1.
Figure 1

Figure 1. From: Differential gene expression and a functional analysis of PCB-exposed children: Understanding disease and disorder development.

Heat-Map showing the hierarchical clustering of differentially expressed genes (162) that up regulated (red) and down regulated (green) between High PCB and Low PCB groups (p<0.00001). Dendrogram displayed the clustering results systematically.

Sisir K Dutta, et al. Environ Int. ;40:143-154.
2.
Figure 5

Figure 5. From: Differential gene expression and a functional analysis of PCB-exposed children: Understanding disease and disorder development.

The important toxicological functions with the differentially expressed gene set in high PCB exposure as obtained through IPA analysis for toxicological functions. The threshold line in the bar chart represents a p-value of 0.05

Sisir K Dutta, et al. Environ Int. ;40:143-154.
3.
Figure 6

Figure 6. From: Differential gene expression and a functional analysis of PCB-exposed children: Understanding disease and disorder development.

The overlay of significant canonical pathway and the connectivity in the molecular mechanism of cancer, with the eight genes in IPA canonical pathway and with the genes in Network (I) that differentially altered in PCB exposure. Solid interconnecting lines shows the genes that are directly connected and the dotted lines signify indirect connection between the genes with the gene regulation and functions attributed by their shape and denoted.

Sisir K Dutta, et al. Environ Int. ;40:143-154.
4.
Figure 2

Figure 2. From: Differential gene expression and a functional analysis of PCB-exposed children: Understanding disease and disorder development.

Relationship between gene expression alterations and relative changes in the top biofunctions obtained through Functional analysis for the dataset of differentially expressed genes (p<0.00001) in High PCB exposure in the subcategory of Molecular and Cellular Functions(A), Physiological System Development and Function (B), and Disease and Disorders development (C).

Sisir K Dutta, et al. Environ Int. ;40:143-154.
5.
Figure 3

Figure 3. From: Differential gene expression and a functional analysis of PCB-exposed children: Understanding disease and disorder development.

The top two of the major networks by differentially expressed gene set in high PCB exposure showing the connectivity of differentially expressed genes. Solid interconnecting lines shows the genes that are directly connected and the dotted lines signify indirect connection between the genes with the gene regulation and functions attributed by their shape and denoted. Net work (I) consist with six down regulated and eight up-regulated genes and Net work (II) consist with five down regulated and eight up-regulated genes.

Sisir K Dutta, et al. Environ Int. ;40:143-154.
6.
Figure 4

Figure 4. From: Differential gene expression and a functional analysis of PCB-exposed children: Understanding disease and disorder development.

The significant canonical pathways involved in the well-characterized cell signaling and metabolic pathways associated with the genes that differentially expressed in High PCB exposure. The threshold line in the bar chart represents a p-value of 0.05. The ratio (r) is calculated by the number of genes from the our data set of differentially expressed gene set that participate in a Canonical Pathway, and dividing it by the total number of genes in that Canonical Pathway in IPA analysis.

Sisir K Dutta, et al. Environ Int. ;40:143-154.

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