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Results: 5

1.
Figure 3

Figure 3. From: Reducing Non-Infectious Risks of Blood Transfusion.

Influence of universal leukoreduction on mortality, infection, fever, and antibiotic use, re-printed from Hebert et al21. CI, confidence interval; OR, odds ratio.

Brian M. Gilliss, et al. Anesthesiology. ;115(3):635-649.
2.
Figure 1

Figure 1. From: Reducing Non-Infectious Risks of Blood Transfusion.

Approach to distinguishing TRALI from TACO. BNP, B-type natriuretic peptide; BP, blood pressure; ECG, electrocardiogram; TACO, transfusion-associated circulatory overload; ALI, acute lung injury; TRALI, transfusion-related acute lung injury. modified from Gajic et al.26

Brian M. Gilliss, et al. Anesthesiology. ;115(3):635-649.
3.
Figure 4

Figure 4. From: Reducing Non-Infectious Risks of Blood Transfusion.

(A) Total reported adverse events vs. reports of TRALI to the SHOT Program 1996–2009. Use of male-only plasma was initiated in 2003. (grey bars, TRALI reports; black bars, total adverse events) (B) Components implicated in TRALI 2002–2008. TRALI events associated with FFP and platelets fell after the transition to male only plasma was initiated in 2003. (grey bars, number of cases with FFP or Platelets implicated; black bars, number of cases with red cell units implicated). FFP, fresh frozen plasma; TRALI, transfusion-related acute lung injury; SHOT, Serious Hazards of Transfusion. adapted from: Annual Report 2008. Serious Hazards of Transfusion, 2008, accessed 12/14/10 from: http://www.shotuk.org/shot-reports/

Brian M. Gilliss, et al. Anesthesiology. ;115(3):635-649.
4.
Figure 2

Figure 2. From: Reducing Non-Infectious Risks of Blood Transfusion.

Schematic of the pathogenesis of TRALI. Neutrophils are activated by a “first hit” which is commonly surgery, trauma, or sepsis (not shown). The “second hit” is transfusion, which may introduce anti-HLA, anti-neutrophil antibodies, or other biologic response modifiers such as lyso-PC, a lipid product of cell membrane breakdown. The resulting injury results in protein leak, pulmonary edema, and release of factors which amplify the inflammatory response. lyso-PC, lysophosphatidylcholine; PMN, neutrophil; Anti-HLAAb; anti human leukocyte antigen antibody; MMP, matrix metalloproteinase; TNF, tumor necrosis factor.

Brian M. Gilliss, et al. Anesthesiology. ;115(3):635-649.
5.
Figure 5

Figure 5. From: Reducing Non-Infectious Risks of Blood Transfusion.

Change in stored red blood cell characteristics over time. RBC 2,3-DPG (A), potassium (B), pH (C), lactate (D), pO2 (E), SO2 (F), cell-free hemoglobin in storage medium (G), and RBC surface phosphatidyl serine (PS) expression (H) as a function of storage time. Data are median with 25th and 75th percentiles. P values represent significance for change over time. RBC 2,3-DPG, red blood cell 2,3-diphosphoglycerate; pO2, partial pressure of oxygen; HbSO2, percent of hemoglobin saturated with oxygen; Free Hb, free hemoglobin; RBC Surface PS Expression, red blood cell surface phosphatidyl serine expression. re-printed from Bennett-Guerrero et al76, Copyright 2007 National Academy of Sciences, U.S.A.

Brian M. Gilliss, et al. Anesthesiology. ;115(3):635-649.

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