Figure 1

Figure 1. From: Molecular Nevogenesis.

Relative position of RAS, RAF, and GNAQ in intracellular signaling. Mutations in NRAS, HRAS<BRAF, and GNAQ lead to alterations in transcription factor expression (MIT-F and Brn2 not shown). This in turn drives a number of processes like cell cycle progression. The contribution of the transcription factor Myc to cell cycle progression and its relationship to tumor suppressors are shown downstream of the aforementioned mutations.

Andrew L. Ross, et al. Dermatol Res Pract. 2011;2011:463184.

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