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Results: 4

1.
Figure 4

Figure 4. From: Consistent t(1;10) with Rearrangements of TGFBR3 and MGEA5 in both Myxoinflammatory Fibroblastic Sarcoma and Hemosiderotic Fibrolipomatous Tumor.

Partial GTG banded karyotype of a tumor with mixed MIFS/HFLT morphologic appearance. The two clonal populations (A,B) as well as the single abnormal metaphases (C,D) showed consistent der(10) evolving from a t(1;10), but variable alterations in chromosomes 1 and 3.

Cristina R Antonescu, et al. Genes Chromosomes Cancer. ;50(10):757-764.
2.
Figure 2

Figure 2. From: Consistent t(1;10) with Rearrangements of TGFBR3 and MGEA5 in both Myxoinflammatory Fibroblastic Sarcoma and Hemosiderotic Fibrolipomatous Tumor.

Distribution of BAC probe sets tested, flanking: A. TGFBR3 on 1p22, inset shows a pair of fused normal signals, and a single green signal, suggesting deletion of the centromeric red signal; B. MGEA5 on 10q24, inset showing loss of the green, telomeric part and by FISH; and C. VGLL3 (probe covering the gene in green) on 3p12.1, inset showing high level amplification in a MIFS lesion (probe at 3p22.1 in red used as reference).

Cristina R Antonescu, et al. Genes Chromosomes Cancer. ;50(10):757-764.
3.
Figure 3

Figure 3. From: Consistent t(1;10) with Rearrangements of TGFBR3 and MGEA5 in both Myxoinflammatory Fibroblastic Sarcoma and Hemosiderotic Fibrolipomatous Tumor.

Cytogenetic and FISH results in HFLT. A. Partial karyotype showing an apparently balanced t(1;10)(p22;q24) in a HFLT foot lesion from a 32 year-old female; which by FISH showed the presence of TGFBR3 gene rearrangement, with the deletion of the centromeric part (B, red) and MGEA5 rearrangement with the deletion of the telomeric part (C, green). FISH analysis using centromeric MGEA5 (red) and telomeric TGFBR3 (green) probes showed a fused signal in a 42 year-old female with a left ankle lesion with mixed MIFS/HFLT morphology (D).

Cristina R Antonescu, et al. Genes Chromosomes Cancer. ;50(10):757-764.
4.
Figure 1

Figure 1. From: Consistent t(1;10) with Rearrangements of TGFBR3 and MGEA5 in both Myxoinflammatory Fibroblastic Sarcoma and Hemosiderotic Fibrolipomatous Tumor.

Pathologic appearance of the investigational and control groups. A. Ray amputation specimen showing a 7 cm circumferential subcutaneus MIFS, with a fleshy tan cut surface; which showed microscopically a spindle and pleomorphic cellular proliferation embedded in a myxoid stroma (B, 200×), with pseudo-lipoblasts and inclusion type nucleoli (C, 400×); HFLT composed of mature adipose fat infiltrated by a bland spindle cell proliferation (D, 100×), showing abundant hemosiderin-deposition and multinucleated giant cells (E, 400×); increased vascular proliferation composed of medium sized blood vessels is a common finding at the periphery of HFLT (F, 100×); 44 ear old female with a foot lesion showing areas of MIFS (G, 100×), blending with areas of HFLT (H, 100×). From the control group, one PHAT tumor from the thigh of a 45 year old female, showed the classic appearance of spindle cells with distinct pleomorphism and fibrinoid changes within dilated blood vessels (I, 100×); in addition, at the periphery of the lesion, an infiltrative component within the fat known as ‘early PHAT’, resembled the HFLT appearance (J, 200×; K, 400×, inset).

Cristina R Antonescu, et al. Genes Chromosomes Cancer. ;50(10):757-764.

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