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1.
Fig. 2

Fig. 2. Responsiveness of ‘Th2-high’ asthma to inhaled steroids in a randomized placebo-controlled trial. From: Human asthma phenotypes: from the clinic, to cytokines, and back again.

FEV1 measured at baseline (week 0), after 4 and 8 weeks on daily fluticasone (500μg BID), and one week after the cessation of fluticasone (week 9). N=6 Th2-low on fluticasone (blue line), 10 Th2-high on fluticasone (red) and 11 on placebo (black). * denotes p<0.05 for comparison with placebo.

Nirav R. Bhakta, et al. Immunol Rev. ;242(1):220-232.
2.
Fig. 1

Fig. 1. Expression levels of three IL-13 induced genes in the airway define two subgroups of asthmatics. From: Human asthma phenotypes: from the clinic, to cytokines, and back again.

(A) Heatmap depicting unsupervised hierarchical clustering (Euclidean complete) of POSTN, CLCA1, and SERPINB2 expression levels in bronchial epithelial brushings across 42 subjects with asthma (denoted by ‘A’) and 28 healthy controls (‘H’). (B) Mean (+ SEM) expression levels of IL-4, IL-5, and IL-13 in bronchial biopsy homogenates obtained contemporaneously with bronchial brushings from a subset of subjects depicted in Figure 1A (cluster 1: 18 ‘Th2-high’ asthmatics, red bars; cluster 2: 14 healthy controls, grey bars, and 16 ‘Th2-low’ asthmatics, blue bars). Two-way correlations across all subjects between IL-4, IL-5, and IL-13 indicated at right (Spearman’s rank correlation).

Nirav R. Bhakta, et al. Immunol Rev. ;242(1):220-232.

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