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1.
FIG. 9

FIG. 9. From: QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) Using Venular-Targeted Velocity-Selective Spin Labeling.

Quantitative Yv (left), OEF (middle), and CMRO2 (right) maps for representative subject, created by applying QUIXOTIC theory on a voxel-by-voxel basis.

D. S. Bolar, et al. Magn Reson Med. ;66(6):1550-1562.
2.
FIG. 5

FIG. 5. From: QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) Using Venular-Targeted Velocity-Selective Spin Labeling.

TRUST (top) and QUIXOTIC (bottom) mean difference images from representative subject. Mean difference images are an average of many control–tag subtractions and reflect sagittal-sinus blood weighting in TRUST and venular blood weighting in QUIXOTIC.

D. S. Bolar, et al. Magn Reson Med. ;66(6):1550-1562.
3.
FIG. 6

FIG. 6. From: QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) Using Venular-Targeted Velocity-Selective Spin Labeling.

Representative CBF image (top-left), DIR image (bottom-left), and anatomical MP-RAGE with prescribed slice overlay (right). QUIXOTIC, ASL, and DIR sequences acquired data in this slice orientation.

D. S. Bolar, et al. Magn Reson Med. ;66(6):1550-1562.
4.
FIG. 10

FIG. 10. From: QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) Using Venular-Targeted Velocity-Selective Spin Labeling.

Yv versus TO (a) and Yv versus VCUTOFF (b) for the parameter exploration data acquired with turbo QUIXOTIC in three reimaged subjects. Error bars represent the SEE.

D. S. Bolar, et al. Magn Reson Med. ;66(6):1550-1562.
5.
FIG. 1

FIG. 1. From: QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) Using Venular-Targeted Velocity-Selective Spin Labeling.

QUIXOTIC pulse sequence timing diagram. Sequence is played once for control image generation and repeated for tag image generation. What differs between control and tag acquisition is velocity weighting in the VS2/T2-preparation module.

D. S. Bolar, et al. Magn Reson Med. ;66(6):1550-1562.
6.
FIG. 2

FIG. 2. From: QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) Using Venular-Targeted Velocity-Selective Spin Labeling.

Mz modulation produced by velocity selective pulse; ideal filter (black rect function) and implemented filter (blue sinc function), given example VCUTOFF of 1 cm/s. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

D. S. Bolar, et al. Magn Reson Med. ;66(6):1550-1562.
7.
FIG. 8

FIG. 8. From: QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) Using Venular-Targeted Velocity-Selective Spin Labeling.

Representative T2 versus Y calibration curves for the representative subject, generated with microvascular (red) and macrovascular (blue) hematocrit, using Eq. 7. These curves are used to calibrate T2 to blood oxygen saturation for the QUIXOTIC and TRUST experiments. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

D. S. Bolar, et al. Magn Reson Med. ;66(6):1550-1562.
8.
FIG. 4

FIG. 4. From: QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) Using Venular-Targeted Velocity-Selective Spin Labeling.

Idealized cartoon of venular blood signal targeting in QUIXOTIC approach, as told via spin configuration throughout the experiment. Relaxed spins are denoted by upright arrows; dephased spins by hollow circles. Dotted vertical lines correspond to 1 cm/s blood velocity (i.e., the cutoff velocity in b and d).

D. S. Bolar, et al. Magn Reson Med. ;66(6):1550-1562.
9.
FIG. 3

FIG. 3. From: QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) Using Venular-Targeted Velocity-Selective Spin Labeling.

Velocity selective module: real (blue) and imaginary (red) RF waveforms (top) and gradient waveform (bottom). Degree of velocity weighting (i.e., the cutoff velocity, VCUTOFF) is defined by the gradient strength (G), gradient duration (δ), and gradient separation (Δ). Disabling velocity selectivity implies G = 0. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

D. S. Bolar, et al. Magn Reson Med. ;66(6):1550-1562.
10.
FIG. 7

FIG. 7. From: QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) Using Venular-Targeted Velocity-Selective Spin Labeling.

TRUST and QUIXOTIC log(SI) versus effective echo time curves and corresponding T2 fits for all 10 subjects. Vertical offset of the fit lines have been normalized for minimum variance within TRUST and QUIXOTIC datasets. Solid blue and red lines represent mean T2 fit curves for all 10 subjects, for TRUST and QUIXOTIC, respectively. The vertical intercept estimates the imaging blood volume within sagittal sinus and GM voxels for TRUST and QUIXOTIC, respectively. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]

D. S. Bolar, et al. Magn Reson Med. ;66(6):1550-1562.

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