Results: 2

1.
Figure 1

Figure 1. From: The Hypoxia-Inflammation Link and Potential Drug Targets.

Overview of clinical conditions characterized primarily by tissue hypoxia resulting in inflammatory changes (left), or inflammatory diseases that lead to tissue hypoxia (right; from the New England Journal of Medicine with permission1).

Michael Koeppen, et al. Curr Opin Anaesthesiol. ;24(4):363-369.
2.
Figure 2

Figure 2. Regulation of hypoxia-inducible factor (HIF) protein levels under normoxic or hypoxic conditions. From: The Hypoxia-Inflammation Link and Potential Drug Targets.

In normoxia, hydroxylation at 2 proline residues promotes HIF-α association with pVHL and HIF-α destruction via the ubiquitin/proteasome pathway, while hydroxylation of an asparagine residue blocks association with coactivators. In hypoxia, these processes are suppressed, allowing HIF-α subunits (both HIF-1α and HIF-2α) to escape proteolysis, dimerize with HIF-1β, recruit coactivators, and activate transcription via HREs. N, asparagine; P, proline; OH, hydroxyl group; Ub, ubiquitin [modified, from the Journal of Clinical Investigation with permission 62].

Michael Koeppen, et al. Curr Opin Anaesthesiol. ;24(4):363-369.

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