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1.
Figure 2

Figure 2. From: Multi-band Frequency Encoding Method for Metabolic Imaging with Hyperpolarized [1-13C]Pyruvate.

Axial imaging of a cylindrical multi-chamber 13C phantom (d= 5.6 cm) with internal spheres (d= 2.3 cm) containing enriched 13C-pyruvate, -alanine, and -lactate. Nominal spatial resolution of 13C image acquisition was 7.5 mm in-plane. Top row: Individual reconstructed 13C metabolite images. Bottom row: 1H FSE image and composite image overlay.

Cornelius von Morze, et al. J Magn Reson. ;211(2):109-113.
2.
Figure 1

Figure 1. From: Multi-band Frequency Encoding Method for Metabolic Imaging with Hyperpolarized [1-13C]Pyruvate.

Schematic representation of multi-band frequency encoding method, showing spread of metabolite signals into adjacent, non-overlapping frequency bands used for spatial encoding, when a correctly chosen frequency encoding gradient is activated. All quantities are as defined in the text.

Cornelius von Morze, et al. J Magn Reson. ;211(2):109-113.
3.
Figure 5

Figure 5. From: Multi-band Frequency Encoding Method for Metabolic Imaging with Hyperpolarized [1-13C]Pyruvate.

Pelvic / abdominal metabolite distribution from two transgenic prostate cancer (TRAMP) mice imaged using multi-band frequency encoding. (left-to-right = inferior-to-superior). In the mouse at top, lactate is well localized to the region of gross tumor as defined on T2w 1H images.

Cornelius von Morze, et al. J Magn Reson. ;211(2):109-113.
4.
Figure 4

Figure 4. From: Multi-band Frequency Encoding Method for Metabolic Imaging with Hyperpolarized [1-13C]Pyruvate.

Axial imaging of hyperpolarized [1-13C]pyruvate and its metabolic products by multiband frequency encoding in a normal mouse. All individual metabolite images from stack are shown, overlaid on co-registered T2w 1H images, with anatomic landmarks. Alanine signal is mostly localized to the liver, due to highest expression of alanine transaminase.

Cornelius von Morze, et al. J Magn Reson. ;211(2):109-113.
5.
Figure 6

Figure 6. From: Multi-band Frequency Encoding Method for Metabolic Imaging with Hyperpolarized [1-13C]Pyruvate.

Plots of point spread function for MBFE imaging method (Eq. 5) as described for animal experiments, including effects of T2* blurring and symmetric windowed Fourier sampling, computed for various possible T2* values to reflect different levels of intravoxel inhomogeneity. Red- infinite, blue- 380 ms, magenta- 125 ms, black- 38 ms.

Cornelius von Morze, et al. J Magn Reson. ;211(2):109-113.
6.
Figure 3

Figure 3. From: Multi-band Frequency Encoding Method for Metabolic Imaging with Hyperpolarized [1-13C]Pyruvate.

Separation of pyruvate, alanine, and lactate images in a normal mouse by multi-band frequency encoding method. Nominal resolution was 3 mm in-plane by 5 mm slice. Liver slice was selected for high concentration of all three metabolites. Pyruvate image (green box) occupies top frequency encoding band in raw 13C imaging data, with alanine (blue) and lactate (red) images below. Reconstructed composite image overlays shown at right.

Cornelius von Morze, et al. J Magn Reson. ;211(2):109-113.

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