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1.

Figure 1. From: Biomarkers in AD drug development: can't live without 'em.

Figure 1a. Spaghetti plots of ADAScog13 in MCI. Rise in scores over two years is disorderly, with low signal to noise ratio. Figure 1b. In contrast, change in hippocampal voilume is more linear and parallel.

Paul S. Aisen. Alzheimers Dement. ;7(3):e48-e50.
2.

Figure 2. From: Biomarkers in AD drug development: can't live without 'em.

Figure 2a, Longitudinal change in ADAScog13 score in MCI. Figure 2b, longitudinal change in hippocampal volume in MCI, showing better signal (magnitude of change over time) to noise (size of error bars) ratio. All figures generated by Michael Donohue using data from the Alzheimer's Disease Neuroimaging Initiative (10), downloaded on May 28, 2010.

Paul S. Aisen. Alzheimers Dement. ;7(3):e48-e50.

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