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Results: 3

1.
Fig. 3

Fig. 3. From: Vaccination of guinea pigs using mce operon mutants of Mycobacterium tuberculosis.

Percentage degree of consolidated lung in each experimental group. Data shown as mean + SEM (n=4-5guinea pigs). Three vaccines gave reduced consolidation compared to the BCG control (*p<0.05, ** p<0.01, by ANOVA).

Andrés Obregón-Henao, et al. Vaccine. ;29(26):4302-4307.
2.
Fig. 1

Fig. 1. From: Vaccination of guinea pigs using mce operon mutants of Mycobacterium tuberculosis.

Day-30 protection assay in guinea pigs immunized with the Δmce mutants or with BCG, and challenged by low dose aerosol with M. tuberculosis. The highly virulent W-Beijing strain SA161 was used as the challenge strain. Data is shown as the log10 of the mean lung and spleen burden values ± SEM [n=5]. Significantly higher reduction of lung bacterial burden was observed when guinea pigs were vaccinated with BCG, ΔMce-1, ΔMce3.1 and ΔMce3.3 (**p<0.01) than when vaccinated with ΔMce-2 (*p<0.05 by ANOVA). In the spleen, BCG vaccination significantly reduced bacterial burden (**p<0.01 by student t-test).

Andrés Obregón-Henao, et al. Vaccine. ;29(26):4302-4307.
3.
Fig. 2

Fig. 2. From: Vaccination of guinea pigs using mce operon mutants of Mycobacterium tuberculosis.

Vaccination of guinea pigs with Mce vaccines significantly reduces lung pathology after challenge with a highly virulent W-Beijing isolate. Sham vaccination with saline followed by low dose aerosol infection with M. tuberculosis SA161 produced multiple primary granulomatous lesions with extensive central necrosis (arrow) A-B. In contrast, vaccination with, Δ-Mce1 C-D, Δ-Mce2 E-F, Δ-Mce3.1G-H, or Δ-Mce3.3 I-J resulted in better protection characterized by significantly fewer and smaller primary lesions with minimal central necrosis (arrows) that was improved compared to animals vaccinated with BCG K-L. Hematoxylin and eosin, A,C,E,G,I,K mag. 2.5×, B, D, F, H, J, L mag. 100×.

Andrés Obregón-Henao, et al. Vaccine. ;29(26):4302-4307.

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