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Results: 4

1.

Figure. From: Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis.

Fig 1 Influence of personal calcium supplement dose at randomisation on the effect of calcium and vitamin D on cardiovascular events in the WHI CaD Study

Mark J Bolland, et al. BMJ. 2011;342:d2040.
2.

Figure. From: Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis.

Fig 3 Effect of calcium supplements with or without vitamin D on cardiovascular events: based on patient-level data. The panels show the time to first event for 24 869 participants in five trials of calcium supplements,1 8 11 12 13 14 15 and the WHI CaD Study participants not taking personal calcium supplements at baseline

Mark J Bolland, et al. BMJ. 2011;342:d2040.
3.

Figure. From: Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis.

Fig 2 Effect of calcium and vitamin D on cardiovascular events: based on trial-level data from two randomised, placebo controlled trials of calcium and vitamin D8 9 and the WHI CaD Study participants not taking personal calcium supplements at baseline. The first two trials included calcium monotherapy and calcium and vitamin D groups: we included data only from the calcium and vitamin D group compared with the placebo group

Mark J Bolland, et al. BMJ. 2011;342:d2040.
4.

Figure. From: Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis.

Fig 4 Effect of calcium supplements with or without vitamin D on cardiovascular events: trial-level data. The panels show data for 28 072 participants in eight trials of calcium supplements with complete trial-level data,1 8 9 11 12 13 14 15 16 17 plus data for the WHI CaD Study participants not taking personal calcium supplements at baseline. Lappe et al9 randomised participants to calcium, calcium and vitamin D, or placebo: we pooled the outcomes from both the calcium and calcium and vitamin D arms. Grant et al8included calcium v placebo arms (“Grant 2005”) and calcium plus vitamin D v vitamin D plus placebo arms (“Grant 2005 Vit D”). The composite outcome for Prince et al16 was myocardial infarction, stroke, or sudden death

Mark J Bolland, et al. BMJ. 2011;342:d2040.

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