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1.
Figure 2

Figure 2. From: Discovery and replication of dopamine-related gene effects on caudate volume in young and elderly populations (N=1198) using genome-wide search.

Detailed view of the associated locus. Markers are represented as circles (SNPs with no known function) or downward-pointing triangles (coding non-synonymous mutations). Markers are placed at their position on chromosome 5 (x-axis) and graphed based on the −log10(P-values) of their association to the phenotype (y-axis). The level of linkage disequilibrium to the most associated SNP (rs163030) is represented in color using the CEU panel from HapMap Phase II. The location of genes is shown below the plots. Images were created using LocusZoom (http://csg.sph.umich.edu/locuszoom/).

Jason L. Stein, et al. Mol Psychiatry. ;16(9):927-881.
2.
Figure 1

Figure 1. From: Discovery and replication of dopamine-related gene effects on caudate volume in young and elderly populations (N=1198) using genome-wide search.

Manhattan plots show the significance of association of each SNP with caudate volume, from genome-wide association analysis conducted in the ADNI cohort. Each marker is represented as a dot and the −log10(P-value) is displayed on the y-axis. Association was conducted separately for average bilateral (top), left (middle), and right (bottom) caudate volumes. Markers above the blue line represent a P-value < 1×10−5. ChrXY represents the pseudo-autosomal region of the X chromosome, and ChrMT represents mitochondrial SNPs. BLTS Manhattan plots are shown in Supplementary Figure 4.

Jason L. Stein, et al. Mol Psychiatry. ;16(9):927-881.

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