Figure 1

Figure 1. Potential impact of resistin on human disease. From: Human Resistin: Found in Translation From Mouse to Man.

Resistin is upregulated in response to genetic signals and various stimuli. As shown in studies of both human and animals, resistin may act on multiple cell types to promote inflammation, insulin resistance and cardiac pathology. Abbreviations: LPS, lipopolysaccharide; TNFα, tumor necrosis factor-alpha; IL-6, interleukin-6; IL-1β, interleukin-1beta; TZD, thiazolidinedione; PBMC, peripheral blood mononuclear cell; AMPK, adenosine monophosphate-activated protein kinase; SOCS-3, suppressor of cytokine signaling-3; NFkB, nuclear factor kappa B; VCAM-1, vascular cell adhesion molecule-1; ICAM-1, inter-cellular adhesion molecule-1; MCP-1, monocyte chemoattractant protein-1; ET-1, endothelin-1; MAPK, mitogen activated protein kinase.

Daniel R. Schwartz, et al. Trends Endocrinol Metab. ;22(7):259-265.

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