Results: 5

1.
Fig. 3.

Fig. 3. From: CD4+ T Cells, Including Th17 and Cycling Subsets, Are Intact in the Gut Mucosa of HIV-1-Infected Long-Term Nonprogressors.

The proportion of CD4+ (A, C, and D) or CD8+ (B, E, and F) T cells with activated (HLA-DR+ CD38+) (A and B) or cycling (Ki67+) (C to F) phenotype was quantified by flow cytometry. Activation phenotype was determined only for PBMC. Mann-Whitney tests were used for between-group comparisons.

Emily J. Ciccone, et al. J Virol. 2011 June;85(12):5880-5888.
2.
Fig. 1.

Fig. 1. From: CD4+ T Cells, Including Th17 and Cycling Subsets, Are Intact in the Gut Mucosa of HIV-1-Infected Long-Term Nonprogressors.

The proportion (A) or absolute number (B) of CD4+ and CD8+ T cells in the peripheral blood and colon of HIV (blue triangles), VL<50 (black circles), or LTNP (green squares) subjects. Mann-Whitney tests were used for statistical comparisons between groups.

Emily J. Ciccone, et al. J Virol. 2011 June;85(12):5880-5888.
3.
Fig. 5.

Fig. 5. From: CD4+ T Cells, Including Th17 and Cycling Subsets, Are Intact in the Gut Mucosa of HIV-1-Infected Long-Term Nonprogressors.

Plasma levels of LPS and sCD14 were measured for participants who underwent biopsy (A) as well as an expanded cohort of patients who met the inclusion criteria for the three study groups (HIV, VL<50, and LTNP) (C). P values < 0.05 are shown. Correlations between the proportion of Th17 cells in colon and both LPS and sCD14 in participants who underwent gut biopsy, as well as between peripheral CD4 T cell counts and sCD14 in the expanded cohort, were evaluated using Spearman's rank tests. r values are shown.

Emily J. Ciccone, et al. J Virol. 2011 June;85(12):5880-5888.
4.
Fig. 4.

Fig. 4. From: CD4+ T Cells, Including Th17 and Cycling Subsets, Are Intact in the Gut Mucosa of HIV-1-Infected Long-Term Nonprogressors.

Using the gating strategy detailed for panel A, the proportion of Th1 (IFN-γ+) (B) or Th17 (IL-17+) (C) CD4+ T cells was quantified by flow cytometry after 6 h of stimulation with PMA-ionomycin. Experiments were performed using cryopreserved PBMC and freshly extracted gut tissue cells after overnight rest. Mann-Whitney tests were used for between-group comparisons, and P values < 0.05 are shown. Correlations between the percentage of PB and colon Th17 cells and both the overall proportion (D, left panel) and absolute number (D, right panel) of CD4+ T cells in the gut were evaluated using Spearman's rank tests. r values are shown.

Emily J. Ciccone, et al. J Virol. 2011 June;85(12):5880-5888.
5.
Fig. 2.

Fig. 2. From: CD4+ T Cells, Including Th17 and Cycling Subsets, Are Intact in the Gut Mucosa of HIV-1-Infected Long-Term Nonprogressors.

To evaluate homing of T cells to the gut, the percentage of peripheral blood CD4+ T cells expressing high levels of β7 was quantified by flow cytometry (A). Gating was performed as previously described (10). Between-group differences were evaluated by the Mann-Whitney test. Spearman's rank tests were used to assess correlations with the overall proportion (B, left panel) or absolute number (B, right panel) of CD4+ T cells in the gut mucosa. P values and r values are shown for comparisons including all three study groups and the two HIV+ groups. NS, not significant.

Emily J. Ciccone, et al. J Virol. 2011 June;85(12):5880-5888.

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