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Figure 1

Figure 1. From: A role for phosphorylated Pol II CTD in modulating transcription coupled histone dynamics.

(A) Histone acetyltransferase (HAT) complexes associate with elongating polymerase and acetylate nucleosomes in front of Pol II. Bromodomain-containing remodeling complexes (CRC) that interact with Pol II are able to recognize, bind and evict acetylated histones. The evicted histones, which presumably are hyperacetylated, are reassembled behind elongating Pol II with the aid of histone chaperones such as Asf1 or FACT. The reassembled histones are then rapidly deacetylated by the histone deacetylase complexes (HDACs) associated with Pol II. (B) The hyperacetylated reassembled nucleosomes are potential targets for non-Pol II associated bromodomain-containing complexes. If HDACs are not present to rapidly deacetylate reassembled histones, the histones may be recognized by free bromodomain-containing remodelers and evicted.

Marla M Spain, et al. Transcription. 2011 Mar-Apr;2(2):78-81.

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