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Results: 3

1.
Figure 1

Figure 1. From: CD8+ Lymphocyte Depletion without SIV Infection does not Produce Metabolic Changes or Pathological Abnormalities in the Rhesus Macaque Brain.

Representative 7 Tesla MR spectrum acquired from the frontal cortex an animal prior to CD8 depletion. 1H MR spectra are characterized by resonances primarily arising from N-acetylaspartate and N-acetylaspartylglutamate (collectively referred to as NAA), choline-containing compounds (referred to as Cho), myo-Inositol (MI), creatine-containing compounds (referred to as Cr) and the glutamate and glutamine concentrations (so-called Glx).

Eva-Maria Ratai, et al. J Med Primatol. ;40(5):300-309.
2.
Figure 3

Figure 3. From: CD8+ Lymphocyte Depletion without SIV Infection does not Produce Metabolic Changes or Pathological Abnormalities in the Rhesus Macaque Brain.

Quantitative image analysis of immunohistochemistry reveals no difference between CD8-depleted, uninfected animals (CD8-) and non-CD8-depleted, uninfected controls (Control) in (a) SYN, (b) MAP2, (c) GFAP and (d) IBA-1; however, there are significant differences in SYN, GFAP and IBA-1 between SIV-infected, CD8-depleted animals (SIV+/CD8-) and these two control cohorts. Horizontal bars within boxes represent mean values; height of each box corresponds to standard error of the mean.

Eva-Maria Ratai, et al. J Med Primatol. ;40(5):300-309.
3.
Figure 2

Figure 2. From: CD8+ Lymphocyte Depletion without SIV Infection does not Produce Metabolic Changes or Pathological Abnormalities in the Rhesus Macaque Brain.

Figure 2 (a). Changes in Glx/Cr, NAA/Cr, MI/Cr, and Cho/Cr in the white matter semiovale before and after CD8+ lymphocyte depletion in one representative animal over time. None of the metabolite ratios showed any change due to the anti-CD8 treatment.
Figure 2 (b). Mean NAA/Cr ratios of the four CD8-depleted animals in the white matter (WM), frontal cortex (FC), and basal ganglia (BG) as a function of time post-CD8 depletion. No significant changes in any of the brain regions over time were found.
The error bars represent standard error of the mean (SEM).

Eva-Maria Ratai, et al. J Med Primatol. ;40(5):300-309.

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