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Results: 5

1.
Figure 1

Figure 1. From: Gabapentin Combined with Naltrexone for the Treatment of Alcohol Dependence.

Participant flow into a randomized, double-blind placebo-controlled trial combining naltrexone and gabapentin (for the first 6 weeks) with naltrexone-alone for treatment of alcohol dependence.

Raymond F. Anton, et al. Am J Psychiatry. ;168(7):709-717.
2.
Figure 3

Figure 3. From: Gabapentin Combined with Naltrexone for the Treatment of Alcohol Dependence.

Percent Heavy Drinking Days
Percent heavy drinking days per week during the trial (left panel) and the total over each period (right panel). During the first six weeks, those receiving naltrexone/gabapentin had less heavy drinking days than those receiving naltrexone-alone (p=0.0002) but similar to placebo (p=0.16). These effects faded after gabapentin was stopped (post-gabapentin) phase.

Raymond F. Anton, et al. Am J Psychiatry. ;168(7):709-717.
3.
Figure 4

Figure 4. From: Gabapentin Combined with Naltrexone for the Treatment of Alcohol Dependence.

Drinks Per Drinking Day
Average drinks per drinking day each week during the trial (left panel) and total over each period (right panel). During the first six weeks, those receiving naltrexone/gabapentin had less drinks/drinking day than those receiving naltrexone-alone (p=0.02) and placebo (p=0.01). There were no significant differences after gabapentin was stopped (post-gabapentin) phase.

Raymond F. Anton, et al. Am J Psychiatry. ;168(7):709-717.
4.
Figure 2

Figure 2. From: Gabapentin Combined with Naltrexone for the Treatment of Alcohol Dependence.

Time to First Heavy Drinking Day
Cumulative survival of participants not having a heavy drinking day over the course of the study. During the first six weeks, the naltrexone/gabapentin group had more time to a first heavy drinking day than the naltrexone-alone group (p= 0.04), which in turn was not significantly different than the placebo group. There were no significant differences in the post-gabapentin phase.

Raymond F. Anton, et al. Am J Psychiatry. ;168(7):709-717.
5.
Figure 5

Figure 5. From: Gabapentin Combined with Naltrexone for the Treatment of Alcohol Dependence.

Alcohol Withdrawal History and Treatment Response
Cumulative survival of participants not having a heavy drinking day over the course of the study for those with or without a history of alcohol withdrawal (AW). Those with a history of AW treated with naltrexone/gabapentin had more time to a first heavy drinking day compared to those receiving placebo (p= 0.03). For those without a history of AW there was no difference between medication groups.

Raymond F. Anton, et al. Am J Psychiatry. ;168(7):709-717.

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