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Results: 2

1.
Fig. 2.

Fig. 2. From: Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration.

Effect of intraocular CNTF on visual acuity stabilization. (A) Percentage of subjects losing <15 letters from baseline over 12 mo. (B) Significant effect of CNTF on visual acuity stabilization in the high-dose group with baseline BCVA at 20/63 or better.

Kang Zhang, et al. Proc Natl Acad Sci U S A. 2011 April 12;108(15):6241-6245.
2.
Fig. 1.

Fig. 1. From: Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration.

Effect of high-dose CNTF on the increase of retinal thickness of the right eye of an 85-y-old GA patient. (A) Optical coherence tomography (OCT) volume scans at baseline (Left; 6.42 mm3) and 12 mo (Right; 7.22 mm3). (B) Individual OCT images of the macula at baseline (Left) and 12 mo (Right). The dark areas indicated by arrows show the outer nuclear layer. The images were both obtained as 7 mm long scans offset 5 degrees from the horizontal, beginning at the midpoint of the temporal aspect of the optic nerve. Because these custom scans are oriented with respect to the midpoint of the temporal aspect of the optic nerve, rather than with the presumed foveal center, registration and foveal centration difficulties inherent with time domain Stratus OCT are minimized. Accordingly, these images were obtained from similar, if not identical retinal locations. The variation in choroidal shadowing is not related to differing retinal scan locations; rather, it represents differences in thickness of the overlying layers after treatment with NT-501 and, possibly, to differences in overall image saturation. The qualitative widening of the outer layer complex was observed consistently among subjects.

Kang Zhang, et al. Proc Natl Acad Sci U S A. 2011 April 12;108(15):6241-6245.

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