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Results: 5

1.
Fig. 3

Fig. 3. From: Changes in expression of splice cassettes of NMDA receptor GluN1 subunits within the frontal lobe and memory in mice during aging.

Relationship between learning index from the first 10-second interval in probe trials and protein expression of all GluN1 splice variants (A-C) and the GluN1 subunits containing C2′ cassettes (D-F). Graphs showing relationship between protein expression of all GluN1 subunits (A-C) or C2′ cassettes (D-F) in prefrontal cortex of 4 (A, D), 11 (B, E) and 26 (C, F) month old mice and learning index in the first 10-second interval of the probe trials in a reference memory task. r = Pearson correlation coefficient. The p-values were corrected by p_ACT statistical method (corr. p).

Siba R. Das, et al. Behav Brain Res. ;222(1):122-133.
2.
Fig. 4

Fig. 4. From: Changes in expression of splice cassettes of NMDA receptor GluN1 subunits within the frontal lobe and memory in mice during aging.

Relationship between learning index from probe trial intervals and protein expression of all GluN1 splice variants and the GluN1 subunits containing C1 cassettes. Graphs show relationships between protein expression of all GluN1 subunits (A-C) in prefrontal cortex of 4 (A), 11 (B) and 26 month (C) old animals and learning index in the third 10-second interval calculated across probe trials or between protein expression of C1 cassettes (D-F) in prefrontal cortex of 26 month old mice and learning index in the first (D), second (E) or the third (F) 10-second interval of the probe trials in the reference memory task. r = Pearson correlation coefficient. The p-values were corrected by p_ACT statistical method (corr. p).

Siba R. Das, et al. Behav Brain Res. ;222(1):122-133.
3.
Fig. 2

Fig. 2. From: Changes in expression of splice cassettes of NMDA receptor GluN1 subunits within the frontal lobe and memory in mice during aging.

Protein expression of all NMDA receptor GluN1 subunits and the GluN1 subunits containing the N or C-terminal cassettes. A-E) Graphs showing protein expression of all GluN1 splice variants together (A) and GluN1 subunits containing N-terminal cassette N1 (B) or C-terminal cassettes C1 (C), C2 (D) or C2′ (E) in prefrontal/frontal cortical regions of mouse brain. (F) Representative images of the blots used for quantification of the above-mentioned cassettes and all GluN1 subunits. GAPDH was used as a loading control and data were normalized with the amount of GAPDH expressed in each lane. * p < .05 for difference in expression of protein from 4-months old animals when data were collapsed across behavioral experience groups. Graph bars = mean, error bars = SEM. Statistical analysis performed with ANOVA and Fisher’s protected LSD post-hoc tests.

Siba R. Das, et al. Behav Brain Res. ;222(1):122-133.
4.
Fig. 5

Fig. 5. From: Changes in expression of splice cassettes of NMDA receptor GluN1 subunits within the frontal lobe and memory in mice during aging.

Relationship between high and low C1 cassette expression in aged mice and performance during the probe trials for reference memory. A) Graph showing learning index scores for aged animals with high (H) and low (L) C1 cassette/GAPDH expression during the three different 10-second intervals for probe trials of reference memory. B) Graph showing time taken to reach the former platform location for the first time, indexed across the probe trials, for the three age groups of animals. The 26 month olds were separated into High C1 (H) and Low C1 (L) groups. C) Graph showing the number of times/second that animals from the three age groups reached the platform location during the first 20 and last 10 seconds, averaged across the probe trials for reference memory. The 26 month olds were separated into High C1 (H) and Low C1 (L) groups. D) Swim speed of twenty-six month old animals divided into High C1 and Low C1 groups during the first 20 second and the last 10 second of the probe trials. H = twenty-six month old animals with high C1 cassette protein expression (C1 cassette/GAPDH), L = twenty-six month old animals with low C1 cassette protein expression. % = difference from animals in the second interval of the same C1 group. $ = difference from animals in the first interval of the same C1 group. ^ = difference from animals with low C1 expression in the same interval. * = difference from the four month olds in the same interval or full probe trials. # = difference from the average platform crossings/sec in the first 20 seconds in the same age or C1 group. mo. = months. Graph bars = mean, error bars = SEM.

Siba R. Das, et al. Behav Brain Res. ;222(1):122-133.
5.
Fig. 1

Fig. 1. From: Changes in expression of splice cassettes of NMDA receptor GluN1 subunits within the frontal lobe and memory in mice during aging.

Memory performance of mice in different behavioral tasks. Graphs showing cumulative proximity scores of mice averaged across 12 days of place trials (A) and learning index scores calculated from the full 30s and three 10s intervals of probe trials (B) for the reference memory tasks; cumulative proximity scores for naïve (T0) and delayed (Tdelay) trials (C) and the ratio T0/Tdelay (D) averaged across all working memory sessions, and cued control trials at the 6 different platform positions (E) for the 4, 11 and 26 month old mice. A lower cumulative proximity score (A, C, E) or learning index value (B) indicated more time spent closer to the platform location. * p < .05 for differences from 4-month old animals for the same trials, # p < .05 for differences from 11-month old animals for the same trial(s), ¢ p < .05 for difference from the first interval of probe trial in the same age group, § p < .05 for difference from the second interval of probe trial in the same age group, † p < .05 for differences from overall performance in naïve trials (T0) within same age group. A-C, E) Graph bars = mean, error bars = SEM. Statistical analysis performed with ANOVA and Fisher’s protected LSD post-hoc tests.

Siba R. Das, et al. Behav Brain Res. ;222(1):122-133.

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