We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 3

1.
Fig. 3

Fig. 3. From: Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker.

The ROC curve analysis of intraoperative detection of ALA-induced PpIX. A: Curve for all tumors using visible in vivo fluorescence as a diagnostic variable (AUC = 0.73 ± 0.03). B: Curve for all tumors using quantitative in vivo PpIX concentration, CPpIX, as a diagnostic variable (AUC = 0.95 ± 0.02).

Pablo A. Valdés, et al. J Neurosurg. ;115(1):11-17.
2.
Fig. 2

Fig. 2. From: Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker.

Concentration of ALA-induced PpIX, CPpIX. Circles represent the CPpIX value calculated in vivo using the light-transport model for each location where measurements were collected, with filled circles representing interrogated sites with visible red fluorescence, and open circles representing interrogated sites with no visible fluorescence. The cutoff value is determined from the quantitative probe measurements, and n represents the number of locations measured for controls (CT), all tumors combined (AT), and the 4 tumor categories: LGG, HGG, meningioma (MEN), and metastasis (MET). The y axis is logarithmic. Statistically significant differences in CPpIX were found between normal and abnormal intracranial tissue: all tumors (p < 0.0001), LGGs (p < 0.05), HGGs (p < 0.0001), meningiomas (p < 0.0001), and metastases (p < 0.001).

Pablo A. Valdés, et al. J Neurosurg. ;115(1):11-17.
3.
Fig. 1

Fig. 1. From: Quantitative fluorescence in intracranial tumor: implications for ALA-induced PpIX as an intraoperative biomarker.

In vivo spectroscopic measurements of ALA-induced PpIX fluorescence during intracranial tumor resection surgeries. Left: Intraoperative fluorescence images of the resection cavity visible to the surgeon through the operating microscope under blue light exposure. The arrows indicate the location of the handheld probe tip where the spectroscopic measurements and tissue specimens were acquired. Center: Raw fluorescence spectra (data, green) and modeled quantitative in vivo fluorescence spectra (model fit, red) measured at each interrogated site (the characteristic spectral features of PpIX, that is, emission peaks at λ = 635 nm and λ = 710 nm, are evident). The units for the values on the y axis are nm−1cm−1 and those for the values on the x axis are nm. Right: Histological tissue sections of the specimens (H & E, original magnification × 40). The rows correspond to normal cortex (A–C), LGG (D–F), HGG (G–I), meningioma (J–L), and metastasis (M–O). The HGG displays visible levels of fluorescence while the LGG, meningioma, and metastasis exhibit no visible fluorescence; all of the tumor histologies have measurable CPpIX relative to normal cortex, whose spectrum is devoid of the characteristic signal features of PpIX and its associated photoproducts.

Pablo A. Valdés, et al. J Neurosurg. ;115(1):11-17.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk