We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 3

1.
FIG. 2.

FIG. 2. From: Development of an Inhaled Dry-Powder Formulation of Tobramycin Using PulmoSphere(TM) Technology.

Scanning electron microscope images of: (a) typical micronized drug particles, (b) TIP particles, and (c) TIP particle (closeup).

David E. Geller, et al. J Aerosol Med Pulm Drug Deliv. 2011 August;24(4):175-182.
2.
FIG. 3.

FIG. 3. From: Development of an Inhaled Dry-Powder Formulation of Tobramycin Using PulmoSphere(TM) Technology.

The portable breath-actuated T-326 Inhaler. A hypromellose capsule is loaded into the device by first removing the mouthpiece and inserting the capsule into the chamber. The mouthpiece is screwed back onto the body. The button is depressed to pierce the capsule, and the patient then inhales through the mouthpiece. The capsule rotates rapidly in the chamber causing powder to be emptied from the capsule.

David E. Geller, et al. J Aerosol Med Pulm Drug Deliv. 2011 August;24(4):175-182.
3.
FIG. 1.

FIG. 1. From: Development of an Inhaled Dry-Powder Formulation of Tobramycin Using PulmoSphere(TM) Technology.

Schematic of the PulmoSphereâ„¢ manufacturing process. An emulsion-based feedstock is prepared by high-pressure homogenization. The emulsion consists of oil droplets (Perflubron) dispersed in a continuous water phase. The oil droplets are stabilized by a monolayer of a phospholipid (distearoylphosphatidylcholine). The tobramycin drug substance and calcium chloride excipient are dissolved in the continuous phase of the emulsion. The feedstock is atomized with a twin fluid nozzle into a spray dryer. As the atomized droplets containing dispersed emulsion droplets are dried, the slow diffusing emulsion droplets are concentrated at the droplet interface. As the drying continues, a shell is formed at the surface of the atomized droplet. Eventually, the Perflubron evaporates leaving behind pores in the particle shell. The resulting dry powder comprising porous particles is collected from the airstream with a cyclone separator.

David E. Geller, et al. J Aerosol Med Pulm Drug Deliv. 2011 August;24(4):175-182.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk