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1.
Figure 1

Figure 1. Four Major Radiographic Subtypes of Interstitial Lung Abnormalities. From: Lung Volumes and Emphysema in Smokers with Interstitial Lung Abnormalities.

Each row of radiographs and reconstructions represents data from a single study participant. The images in Panel A are characteristic of centrilobular interstitial lung abnormalities; Panel B, subpleural interstitial lung abnormalities; Panel C, mixed centrilobular and subpleural interstitial lung abnormalities; and Panel D, radiographic interstitial lung disease. The images in the first two columns are three-dimensional reconstructions of an anterior-to-posterior view of the lungs (column 1) and a caudal-to-cephalad view (column 2). The translucent yellow–green represents the lung parenchyma; white, the tracheobronchial tree; opaque green, centrilobular opacities; and opaque orange, subpleural abnormalities. Columns 3 and 4 present axial high-resolution computed tomographic images of the chest, with images in column 3 approximately at the level of the carina and those in column 4 approximately at the level of the right inferior pulmonary vein.

George R. Washko, et al. N Engl J Med. ;364(10):897-906.
2.
Figure 2

Figure 2. Study Enrollment and Findings. From: Lung Volumes and Emphysema in Smokers with Interstitial Lung Abnormalities.

Panel A divides the study participants into three groups according to the classifications established by the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Each group is then broken down according to the subtype of interstitial lung abnormalities (ILA). Patients who could not be classified according to the GOLD criteria had a forced expiratory volume in 1 second (FEV1) that was less than or equal to 80% of the predicted value and a ratio of FEV1 to forced vital capacity (FVC) that was greater than or equal to 0.7. Those patients meeting the criteria for GOLD stages 0 to 1 had an FEV1 that was 80% or more of the predicted value, and those meeting the criteria for GOLD stages 2 through 4 had an FEV1 of less than 80% and a ratio of FEV1 to FVC of less than 0.7.14 Panel B shows FEV1 (percent of predicted value) plotted against the FEV1:FVC (percent of predicted value) for participants with and those without ILA and classifies participants according to the GOLD criteria.14 Panel C is a frequency plot of total lung capacity as a percent of the predicted value10 in participants with and those without ILA. ILD denotes interstitial lung disease.

George R. Washko, et al. N Engl J Med. ;364(10):897-906.

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