We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

Results: 3

1.
Figure 1

Figure 1. From: Association between pH-weighted endogenous amide proton chemical exchange saturation transfer MRI and tissue lactic acidosis during acute ischemic stroke.

Characterization of ischemic lesion with multiparametric perfusion, diffusion, and pH-weighted APT MRI of a representative acute stroke animal with MCAO. The animal showed a large perfusion and diffusion lesion mismatch, whereas the pH-weighted APT lesion agreed reasonably well with the diffusion deficit. ADC, apparent diffusion coefficient; APT, amide proton transfer; CBF, cerebral blood flow; CESTRasym, chemical exchange saturation transfer ratio asymmetry; MCAO, middle cerebral artery occlusion; MRI, magnetic resonance imaging.

Phillip Zhe Sun, et al. J Cereb Blood Flow Metab. 2011 August;31(8):1743-1750.
2.
Figure 2

Figure 2. From: Association between pH-weighted endogenous amide proton chemical exchange saturation transfer MRI and tissue lactic acidosis during acute ischemic stroke.

Measurement of ischemic brain metabolites with PRESS MRS. Spectra were acquired (TR/TE=1,000/144 milliseconds, NA=1,024) from two ROIs: one in the ipsilateral ischemic lesion, which appeared as hyperintensive in DWI images (b=1,000 mm2/milliseconds), and the second one chosen in the contralateral normal area to serve as the reference ROI. The displayed spectra were normalized by choline signal, so that change in brain metabolites can be easily realized. Cho, choline-containing compound; Cr, total creatine; DWI, diffusion-weighted imaging; Glx, glutamate/glutamine; MRS, magnetic resonance spectroscopy; NA, number of average; NAA, N-acetylaspartate; PRESS, point-resolved single voxel spectroscopy; ROI, region of interest; TE, echo time; TR, repetition time.

Phillip Zhe Sun, et al. J Cereb Blood Flow Metab. 2011 August;31(8):1743-1750.
3.
Figure 3

Figure 3. From: Association between pH-weighted endogenous amide proton chemical exchange saturation transfer MRI and tissue lactic acidosis during acute ischemic stroke.

Association between MRS measurement of brain lactate content and multiple MRI parameters (n=10). Linear regression test showed a significant correlation between ADC (D), pH-weighted APT MRI (E), and T1-normalized APT MRI (F) with normalized lactate content (Lac/(Cho+Cr)), whereas no such relationship was found for CBF (A) and relaxation measurements (B, C). ADC, apparent diffusion coefficient; APT, amide proton transfer; ASL, arterial spin labeling; CBF, cerebral blood flow; CESTRasym, chemical exchange saturation transfer ratio asymmetry; Cho, choline-containing compound; Cr, total creatine; MRI, magnetic resonance imaging; MRS, magnetic resonance spectroscopy.

Phillip Zhe Sun, et al. J Cereb Blood Flow Metab. 2011 August;31(8):1743-1750.

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Write to the Help Desk