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Results: 2

1.
Figure 1

Figure 1. Graphical summary (Manhattan plot) of genome-wide association results. From: Large-scale association analyses identifies 13 new susceptibility loci for coronary artery disease.

The x-axis represents the genome in physical order; the y-axis shows -log10 P values for all SNPs. Data from the discovery phase are shown in circles and data from the combined discovery and replication phases in stars. Genes at the significant loci are listed above the signals. Known loci are shown in red and novel loci are shown in blue.

Heribert Schunkert, et al. Nat Genet. ;43(4):333-338.
2.
Figure 2

Figure 2. Example of overlapping association signals for multiple traits at ABO gene region on chromosome 9q34. From: Large-scale association analyses identifies 13 new susceptibility loci for coronary artery disease.

In the upper panel the association signal for coronary disease at the ABO gene region in CARDIoGRAM and the positions and rs-numbers of SNPs in this region are shown. The size of boxes illustrates the number of individuals available for this respective SNP. In the lower panel all SNPs with P-values at genome-wide significance level of P<5×10−8 based on the NHGRI GWA study catalogue (http://www.genome.gov/gwastudies/; accessed on June 28th 2010) for all diseases and traits are shown. The degree of linkage disequilibrium (r2) between the lead SNPs for coronary disease and the other traits is reflected by the colour of the squares (upper panel) and the small bars (lower panel) (dark red (high LD) > faint red (low LD)). SI/CH = sitosterol normalized to cholesterol; CA/CH = campesterol normalized to cholesterol; ALP = alkaline phosphatase; ACE = angiotensin converting enzyme; FVIII = coagulation factor VIII; vWF = von Willebrand Factor.

Heribert Schunkert, et al. Nat Genet. ;43(4):333-338.

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